Condition

Cancer Pain clinical trials and research

• 18Clinical trials
• 39NIH research projects
• 1New in 30 days
• 9Countries

Newest Cancer Pain clinical trials

All recruiting trials (18)

• Phenotype-based Pain Guidance for Head and Neck Cancer-Related Pain (pilot)

  This pilot test sees if tailoring pain treatment to a patient’s pain type can reduce head and neck cancer pain in adults who haven’t started cancer treatment yet.

  Recruiting Phase 2 Shaukat Khanum Memorial Cancer Hospital & Research Centre · Lahore, Punjab Province · NCT07919444

• Triple-target radiosurgery for cancer pain using pituitary and thalamic neuromodulation

  This study tests whether focused brain radiosurgery to the pituitary and specific thalamic regions can reduce pain in adults with cancer that’s not controlled by opioids or other treatments.

  Recruiting Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07605546

• Hydromorphone plus electroacupuncture and ear acupressure for refractory cancer pain

  This trial tests whether adding electroacupuncture and ear acupressure to hydromorphone extended-release tablets helps relieve refractory cancer pain.

  Recruiting Early Phase 1 Qinghai Red Cross Hospital · Xining · NCT07489625

• Tibetree topical herbal plasters for people using opioids for cancer pain

  This trial will try Tibetree topical herbal plasters together with prescribed opioids to see if they reduce localized cancer-related pain for adults who are currently taking short-term oral opioids.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07447856

• Transdiscal versus paravertebral splanchnic nerve neurolysis for upper abdominal cancer pain

  This will test whether the transdiscal or the paravertebral splanchnic nerve neurolysis gives better pain relief for people with severe upper abdominal cancer pain that hasn't responded to medicines.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07445386

• MRI-guided focused ultrasound mesencephalotomy for opioid-resistant head, neck, and brachial cancer pain

  This study will try MRI-guided focused ultrasound to make a tiny, precise lesion in the midbrain to relieve severe, opioid-resistant head, neck, or brachial cancer pain.

  Recruiting University of Virginia · Boston, Massachusetts and 5 other locations · NCT07405645

• Intermittent ESP Block via Subcutaneous Port for Lung Cancer Pain

  This study tests whether giving intermittent erector spinae plane (ESP) blocks through a subcutaneous port can better control chest wall–related cancer pain in adults with advanced lung cancer.

  Recruiting Hanoi Medical University · Hanoi · NCT07396558

• Adding an ultrasound-guided iPACK block to an adductor canal block for pain after knee tumor removal

  This trial will test whether adding an ultrasound-guided iPACK block to an adductor canal block reduces pain and opioid use after surgical removal of tumors around the knee in adults aged 18–65.

  Recruiting National Cancer Institute, Egypt · Cairo · NCT07382297

• Virtual reality cognitive behavioral therapy for chronic cancer pain

  This project tests whether a virtual reality program that delivers cognitive behavioral therapy can help adults with chronic cancer pain feel less pain than a two-dimensional tablet program.

  Recruiting at 2 sites Medstar Health Research Institute · Washington D.C., District of Columbia and 1 other locations · NCT07318519

• Refining multiple AI strategies for automatic pain assessment (RUGGI)

  This project tests whether AI models using wearable sensors, facial video/thermography, and physiological signals can detect and estimate pain in adults with chronic or cancer-related pain.

  Recruiting Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona · Salerno, Italy · NCT07038434

• SSS40 injection for moderate-to-severe bone metastatic cancer pain

  This trial will test whether SSS40, a humanized NGF antibody injection, can reduce moderate-to-severe pain from bone metastases in adults.

  Recruiting Phase 1/2 Shenyang Sunshine Pharmaceutical Co., LTD. · Zhengzhou, Henan · NCT07008703

• Web-based platform for managing cancer pain

  This study is testing a new app that helps people with cancer pain in rural China track their symptoms and communicate better with their doctors.

  Recruiting Phase 3 West China Hospital · Chengdu, Sichuan · NCT06663956

• Using virtual reality meditation to relieve cancer pain

  This study is testing whether virtual reality meditation can help cancer patients manage their chronic pain and improve their quality of life.

  Recruiting Fundação Centro de Controle de Oncologia Do Estado Do Amazonas · Manaus, Amazonas · NCT06328751

• Using Virtual Reality to Manage Symptoms in Cancer Patients

  This study is testing whether a virtual reality program can help cancer patients feel better by reducing pain, fatigue, sleep problems, depression, and anxiety after their treatment.

  Recruiting at 2 sites University of Maryland, Baltimore · Baltimore, Maryland and 1 other locations · NCT06248216

• Web-based intervention for managing cancer pain in Asian American breast cancer survivors

  This study is testing a new online program to help Asian American breast cancer survivors manage their pain and depression better.

  Recruiting Vanderbilt University · Nashville, Tennessee · NCT06085313

• Personalized medicine for cancer treatment

  This study is testing if personalized medicine recommendations can improve how well antidepressants, pain medications, and anti-nausea drugs work for cancer patients by looking at their genetic makeup and medication interactions.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT05830279

• Using virtual reality to help manage pain in GI cancer patients

  This study is testing if virtual reality can help people with GI cancer manage their severe abdominal pain better than standard treatments.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT04907643

• Assessing cancer pain using machine learning and telemedicine

  This study is testing a new way to help cancer patients manage their pain better by using technology and support from healthcare teams while they stay at home.

  Recruiting National Cancer Institute, Naples · Naples, Campania and 1 other locations · NCT04726228

NIH-funded research (39)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms

  A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11609950

• Endosomal signaling and cancer pain control in oral cancer

  A study to understand how signals inside nerve cells and supportive cells contribute to pain in people with oral cancer.

  NIH research New York University · New York, United States · NIH-11607374

• Intervention to reduce opioid stigma in cancer pain for advanced cancer patients

  A patient-friendly plan to help people with advanced cancer manage pain better by reducing stigma around using opioid pain medicines.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11408821

• Safe, digitally-enabled cancer pain care for patients and survivors

  A nationwide Mayo Clinic-led program tests a digitally-supported, team-based approach to managing cancer pain that may help patients and survivors receive better, safer pain care.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11400451

• Truncated TrkB and Oral Cancer Pain in Head and Neck Cancer

  This project looks at a specific brain receptor told to influence pain in people with oral cancer to find new ways to reduce pain without heavy opioids.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11393082

• Understanding how mouth cancer proteases drive pain in patients

  This NIH grant looks at how enzymes in oral cancer tumors may cause pain, aiming to connect specific proteases with how patients feel pain.

  NIH research New York University · New York, United States · NIH-11383790

• Blocking HB-EGF and trigeminal EGFR to reduce oral cancer pain and opioid tolerance

  Blocking HB-EGF and EGFR signals in trigeminal nerve cells to try to reduce severe mouth cancer pain and slow opioid tolerance for people with oral cancer.

  NIH research New York University · New York, United States · NIH-11372499

• Continuous flow production of antibody-loaded nanoparticles for non-opioid oral cancer pain relief

  A non-opioid approach using antibody-packed nanoparticles is being developed to relieve oral cancer pain and improve quality of life.

  NIH research New York University · New York, United States · NIH-11355746

• Equitable Access to Buprenorphine for Cancer Pain in Veterans

  A VA study will explore how to fairly bring buprenorphine, a safer pain medication, to Veterans with cancer who are not currently getting it.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11349358

• Nerves inside head and neck tumors and pain

  This research looks at how nerve cells inside head and neck tumors cause pain, with the goal of helping people who have head and neck cancer.

  NIH research Sanford Research/usd · Sioux Falls, United States · NIH-11303285

• How State Cannabis Laws Affect Cancer Pain Care and Patient Well-being

  This project looks at how state laws about cannabis might change how people with cancer manage their pain and how they feel overall.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11260805

• Safe, comprehensive digital cancer pain care (ASCENT)

  A digital care program aims to help adults with advanced cancer get safer, more complete pain treatment.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11187218

• Tech-based pain support for Asian American breast cancer survivors

  This project is building an easy-to-use web and mobile program to help Asian American breast cancer survivors with chronic pain and depression get personalized information and coaching.

  NIH research University of Texas at Austin · Austin, United States · NIH-11179187

• Impact of Cannabis Laws on Cancer Pain in Patients

  A mixed-methods study exploring how state cannabis laws affect cancer pain management and outcomes for adults with cancer.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11145188

• New Ways to Manage Cancer Pain with Resolvin D1

  This project looks for new and safer ways to relieve severe cancer pain, especially bone pain, without using opioids.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11137832

• Understanding how the nervous system affects head and neck cancer pain

  This research looks at how the body's stress response system might make head and neck cancer pain worse and how it could affect tumor growth.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11120982

• Investigating a specific protein's role in pain from oral cancer

  This study is looking at how a protein called TrkBT1 affects pain in people with head and neck cancer, with the goal of finding better ways to manage that pain without relying too much on opioids.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11116279

• Using virtual reality to help manage chronic pain in cancer patients

  This study is exploring a new virtual reality device that helps cancer patients manage their chronic pain by taking them to relaxing virtual environments, and it aims to see how well this fun and calming tool works alongside regular pain treatments.

  NIH research Medstar Health Research Institute · Hyattsville, United States · NIH-11115251

• Exploring the use of medical marijuana for chronic pain management in patients on opioids

  This study is looking at whether medical marijuana can help adults with long-lasting nerve pain who are currently using opioids and want to cut back on them, by comparing those who start using medical marijuana right away with those who wait to see if it makes a difference in their pain management.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11088521

• Understanding the causes of pain in oral cancer patients

  This study is looking into why kids with oral cancer feel different levels of pain, so we can find better ways to help them feel more comfortable.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11081863

• Using virtual reality to help manage pain in patients with gastrointestinal cancer

  This study is exploring how virtual reality can help people with severe abdominal pain from digestive tract cancers feel better and improve their quality of life by using VR goggles to experience relaxing environments.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11067805

• Understanding how nerves in tumors affect pain in head and neck cancer

  This study is looking at how certain nerve cells in head and neck cancer tumors might affect pain differently in patients with HPV negative tumors compared to those with HPV positive tumors, and it hopes to find new ways to help manage that pain.

  NIH research Sanford Research/usd · Sioux Falls, United States · NIH-11061424

• Finding better ways to manage chronic pain in cancer survivors

  This study is looking for ways to help cancer survivors who are using opioids for long-term pain relief manage their pain better, by trying out different treatment methods to see if they can reduce opioid use without making pain worse.

  NIH research Veterans Health Administration · Ann Arbor, United States · NIH-11054164

• Training healthcare providers to use hypnosis for managing cancer pain

  This study is teaching cancer care providers how to use hypnosis to help reduce pain for cancer patients, making their treatment experience more comfortable and improving their overall quality of life.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11045708

• Understanding how racism affects cancer pain treatment equity

  This study is looking at how different racial and ethnic groups of cancer patients experience pain management, especially when it comes to using opioids, and aims to find ways to improve pain relief for everyone by understanding their unique challenges.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11041138

• Understanding how certain cells contribute to pain in oral cancer

  This study is looking at how certain cells and a specific channel in the body might cause pain in people with oral cancer, and it aims to find better ways to measure and manage that pain, using mice to help understand the problem.

  NIH research New York University · New York, United States · NIH-11033704

• Using gene therapy to reduce pain in oral cancer patients

  This study is testing a new gene therapy to help relieve severe pain for people with oral cancer by using special methods to deliver genes that can change how pain signals work in the body, aiming to make pain management easier and with fewer side effects.

  NIH research New York University · New York, United States · NIH-11000269

• Understanding and managing advanced cancer pain at home using smart technology

  This study is looking at how people with advanced cancer and their family caregivers manage pain at home, and it wants to use smart technology to create personalized support that makes pain relief easier and more effective for everyone involved.

  NIH research University of Virginia · Charlottesville, United States · NIH-10992612

• Improving cancer pain management for underserved communities

  This study is looking at how to improve pain management for Hispanic/Latinx and rural cancer survivors by using a team-based approach that focuses on their unique needs, so they can get better care and feel more comfortable during their recovery.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10933565

• Improving pain management for Asian American breast cancer survivors using technology

  This study is creating a helpful web app for Asian American breast cancer survivors to make it easier for them to manage their pain while considering their cultural needs and any feelings of depression they might have.

  NIH research University of Texas at Austin · Austin, United States · NIH-10933452

• Investigating the role of artemin in oral cancer pain and development

  This study is looking at how a gene called artemin affects the growth of oral cancer and the pain that comes with it, to see if targeting this gene can help improve treatment and make patients feel better.

  NIH research New York University · New York, United States · NIH-10914113

• Reducing the stigma of opioid use in cancer pain management

  This study is working on a friendly program to help people with advanced cancer pain feel more comfortable using opioids, so they can manage their pain better without worrying about the stigma that comes with it.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10909030

• Investigating a new treatment for cancer pain using Resolvin D1.

  This study is looking at a natural compound called Resolvin D1, which comes from omega-3 fatty acids, to see if it can help relieve severe pain from bone tumors in cancer patients without the risks of addiction that come with opioids.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10894859

• Investigating how the nervous system affects pain in head and neck cancer

  This study is looking at how pain and stress affect people with head and neck cancer, and it’s testing whether a common heart medication can help ease that pain and slow down the cancer.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10877136

• Investigating the use of medical marijuana for chronic pain management in patients on opioids

  This study is looking at whether medical marijuana can help adults with long-lasting pain who are currently using opioids and want to cut back, by comparing those who start using it right away with those who wait, to see how it affects their pain and opioid use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10857167

• Investigating how certain cell receptors contribute to pain in oral cancer

  This study is looking into how certain cell receptors might be causing pain for people with oral cancer, and by gathering information from patients about their pain and tumor samples, researchers hope to better understand how this pain happens and find ways to help.

  NIH research New York University · New York, United States · NIH-10786660

• New cannabinoids for treating cancer pain without addiction

  This study is working on new pain relief options for cancer patients that won't cause addiction like regular painkillers, aiming to help manage pain safely without affecting the brain.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10726405

• Investigating a new approach to manage pain in oral cancer patients

  This study is looking at how a protein called HB-EGF influences pain and how well opioids work for people with oral cancer, and it aims to help improve pain management for patients like you.

  NIH research New York University · New York, United States · NIH-10582847

• Using focused ultrasound to relieve pain in head and neck cancer patients

  This study is looking at a new way to help people with head and neck cancer feel less pain by using a special type of ultrasound that targets the brain, and it’s designed to be safe and easy without the usual side effects of pain meds or surgery.

  NIH research University of Virginia · Charlottesville, United States · NIH-10242191

Related topics

Quick answers

How many Cancer Pain clinical trials are recruiting right now?

18, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (7 trials), China (3 trials), Italy (2 trials), Canada (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 3: 1, Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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