Understanding how certain cells contribute to pain in oral cancer
Defining TRPV4 contribution of Schwann cells to oral cancer pain
['FUNDING_OTHER'] · NEW YORK UNIVERSITY · NIH-11033704
This study is looking at how certain cells and a specific channel in the body might cause pain in people with oral cancer, and it aims to find better ways to measure and manage that pain, using mice to help understand the problem.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11033704 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Schwann cells and a specific ion channel, TRPV4, in causing pain for patients with oral cancer. By studying how these cells respond to pressure and stretching, the research aims to develop new methods for measuring pain sensitivity. The project will utilize mouse models to explore the mechanisms behind oral cancer pain and assess the potential of TRPV4 inhibition as a pain management strategy. Ultimately, the goal is to improve pain relief options for patients suffering from oral cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with oral cancer who experience significant pain.
Not a fit: Patients without a diagnosis of oral cancer or those not experiencing pain related to their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for patients with oral cancer.
How similar studies have performed: Previous research has shown promise in targeting TRPV4 for pain management in other contexts, suggesting potential for success in this area as well.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULPURI, YATENDRA — NEW YORK UNIVERSITY
- Study coordinator: MULPURI, YATENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.