Investigating the role of artemin in oral cancer pain and development
Official title: Artemin overexpression in oral cancer pain and carcinogenesis
Funded at New York University · NIH-10914113 · Data updated 2026-11-12
This study is looking at how a gene called artemin affects the growth of oral cancer and the pain that comes with it, to see if targeting this gene can help improve treatment and make patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $306,247 |
| NIH project number | 5R01CA228525-06 |
| Project ID | NIH-10914113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with oral cancer who are experiencing chronic pain related to their condition.
✕Less likely to help
Patients with oral cancer who do not experience significant pain or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on understanding how the gene artemin contributes to both the development of oral cancer and the severe pain experienced by patients. By examining the mechanisms through which artemin operates in the cancer microenvironment, the study aims to identify whether targeting this gene can help manage cancer progression and alleviate pain. The approach involves precision medicine, tailoring treatments based on individual genetic profiles to improve outcomes for patients suffering from oral cancer. The research will explore the dual role of artemin as both a cancer-promoting gene and a pain mediator.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage oral cancer and reduce associated pain, improving patients' quality of life.
How similar studies have gone: Previous research has shown promise in targeting specific oncogenes for cancer treatment, suggesting that this approach may yield beneficial results.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Albertson, Donna G — New York University
- Study coordinator: Albertson, Donna G
Related research
Other NIH-funded projects on the same topics.
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Endosomal signaling and cancer pain control in oral cancer
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-
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Understanding how mouth cancer proteases drive pain in patients
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Blocking HB-EGF and trigeminal EGFR to reduce oral cancer pain and opioid tolerance
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Continuous flow production of antibody-loaded nanoparticles for non-opioid oral cancer pain relief
A non-opioid approach using antibody-packed nanoparticles is being developed to relieve oral cancer pain and improve quality of life.
-
Investigating a specific protein's role in pain from oral cancer
This study is looking at how a protein called TrkBT1 affects pain in people with head and neck cancer, with the goal of finding better ways to manage that pain without relying too much on opioids.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.