Investigating a specific protein's role in pain from oral cancer
Contribution of Truncated TrkB Isoform in Oral Cancer Pain
This study is looking at how a protein called TrkBT1 affects pain in people with head and neck cancer, with the goal of finding better ways to manage that pain without relying too much on opioids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11116279 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific protein, TrkBT1, contributes to pain experienced by patients with head and neck cancer. The study will explore the relationship between this protein and pain transmission in sensory neurons, particularly in the context of oral squamous cell carcinoma. By examining how TrkBT1 affects pain behaviors and the tumor microenvironment, the research aims to identify new approaches for pain management that could reduce reliance on opioids. The methodology includes both laboratory experiments and potential clinical applications to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck cancer who are experiencing significant pain.
Not a fit: Patients with cancers other than head and neck cancer or those not experiencing pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new pain relief strategies for patients suffering from oral cancer, potentially reducing their dependence on opioids.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for pain management in cancer patients, indicating potential for success in this approach.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Ruparel, Shivani B — University of Texas Hlth Science Center
- Study coordinator: Ruparel, Shivani B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.