Triple-target radiosurgery for cancer pain using pituitary and thalamic neuromodulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses radiosurgery to ablate the pituitary hypophysis and neuromodulate the centromedian and parafascicular thalamic complexes, aiming to relieve medically refractory cancer pain. The targeted dose is 90 Gy, delivered after multidisciplinary planning at UCLA. Eligible participants have high-impact cancer pain despite optimized opioid therapy and have limited options for other interventions. Outcomes will focus on changes in pain levels and tolerability of the treatment in a population with advanced disease and limited survival expectations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female ≥ 18 years of age on day of SRS treatment.
2. Documentation of insufficiently controlled mixed, complex cancer pain based on Brief Pain Inventory (BPI) \>8/10 despite optimization of opioid regimen
3. Not eligible for or willing to undergo further pain-relieving interventions
4. Written informed consent (and assent when applicable) obtained from patient or patient's legal representative and ability for patient to comply with the study requirements and agree to undergo the study's SRS treatment plan.

Exclusion Criteria:

1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
2. Claustrophobia or inability to life flat
3. Inability to undergo routine imaging studies
4. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
5. Current history of intracranial malignancy or brain metastasis
6. Any prior intracranial irradiation
7. Previous history of craniotomy, deep brain stimulation (DBS) or laser interstitial themal therapy (LITT).
8. Presence of intracranial hardware such as leads for DBS or any other material that may interfere with safe treatment.
9. Any comorbidity or condition which would limit full compliance with the protocol

Where it's running

• UCLA / Jonsson Comprehensive Cancer Center
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: William Delery
• Email: WDelery@mednet.ucla.edu
• Phone: 310-825-5111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.