Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Adding an ultrasound-guided iPACK block to an adductor canal block for pain after knee tumor removal

Official title: Analgesic Efficacy of Adding Ultra Sound Guided IPACK Block to Adductor Canal Block for Postoperative Pain Management After Excision of Tumors Around Knee: a Randomized Controlled Trial

Run by National Cancer Institute, Egypt · NCT07382297 · Data updated 2026-11-12

This trial will test whether adding an ultrasound-guided iPACK block to an adductor canal block reduces pain and opioid use after surgical removal of tumors around the knee in adults aged 18–65.

More Cancer Pain trials

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment70 (estimated)
SponsorNational Cancer Institute, Egypt
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedAugust 15, 2025
Main results expectedMay 30, 2026
Study endsJune 30, 2026
Registry record updatedFebruary 2, 2026
Trial IDNCT07382297 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18–65, ASA II–IV, scheduled for excision of tumors around the knee under spinal anesthesia who agree to the study procedures are ideal candidates.

Probably not a fit

Patients with contraindications such as allergy to local anesthetics, neuromuscular disorders, prior knee surgery or infection, refusal, or contraindications to spinal anesthesia are unlikely to benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 18–65 with ASA physical status II–IV undergoing excision of tumors around the knee under spinal anesthesia are randomly assigned to receive an adductor canal block plus an ultrasound-guided iPACK block or to a control arm without peripheral blocks. The study measures time to first rescue analgesia, postoperative morphine consumption, and pain on the visual analogue scale (VAS). Standard non-opioid analgesics are given per protocol and morphine boluses are used for VAS >4. The intervention is performed under ultrasound guidance at a single center (National Cancer Institute, Cairo).

Why it matters

Potential benefit: If successful, the combined ACB+iPACK approach could lower pain scores and opioid needs, helping patients mobilize and recover faster after knee tumor excision.

How similar studies have gone: Prior studies combining ACB and iPACK for other knee procedures have shown improved postoperative pain scores and earlier mobility, though evidence specifically after tumor excision is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Stated willingness to comply with all study procedures and availability for the duration of the study
* American Society of Anesthesiologists (ASA) physical status II-IV.
* Patients undergoing excision of tumors around the knee under spinal anesthesia

Exclusion Criteria:

* Patient refusal.
* Neuromuscular disorders
* Allergy to local anesthetics
* Previous history of knee surgery
* Patients with a prior knee infection
* Contraindications to spinal anesthesia as coagulopathies and severe aortic stenosis.

Where it's running

  • National cancer institute
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.