Adding an ultrasound-guided iPACK block to an adductor canal block for pain after knee tumor removal
Official title: Analgesic Efficacy of Adding Ultra Sound Guided IPACK Block to Adductor Canal Block for Postoperative Pain Management After Excision of Tumors Around Knee: a Randomized Controlled Trial
Run by National Cancer Institute, Egypt · NCT07382297 · Data updated 2026-11-12
This trial will test whether adding an ultrasound-guided iPACK block to an adductor canal block reduces pain and opioid use after surgical removal of tumors around the knee in adults aged 18–65.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | National Cancer Institute, Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | August 15, 2025 |
| Main results expected | May 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | February 2, 2026 |
| Trial ID | NCT07382297 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65, ASA II–IV, scheduled for excision of tumors around the knee under spinal anesthesia who agree to the study procedures are ideal candidates.
✕Probably not a fit
Patients with contraindications such as allergy to local anesthetics, neuromuscular disorders, prior knee surgery or infection, refusal, or contraindications to spinal anesthesia are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults aged 18–65 with ASA physical status II–IV undergoing excision of tumors around the knee under spinal anesthesia are randomly assigned to receive an adductor canal block plus an ultrasound-guided iPACK block or to a control arm without peripheral blocks. The study measures time to first rescue analgesia, postoperative morphine consumption, and pain on the visual analogue scale (VAS). Standard non-opioid analgesics are given per protocol and morphine boluses are used for VAS >4. The intervention is performed under ultrasound guidance at a single center (National Cancer Institute, Cairo).
Why it matters
Potential benefit: If successful, the combined ACB+iPACK approach could lower pain scores and opioid needs, helping patients mobilize and recover faster after knee tumor excision.
How similar studies have gone: Prior studies combining ACB and iPACK for other knee procedures have shown improved postoperative pain scores and earlier mobility, though evidence specifically after tumor excision is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study * American Society of Anesthesiologists (ASA) physical status II-IV. * Patients undergoing excision of tumors around the knee under spinal anesthesia Exclusion Criteria: * Patient refusal. * Neuromuscular disorders * Allergy to local anesthetics * Previous history of knee surgery * Patients with a prior knee infection * Contraindications to spinal anesthesia as coagulopathies and severe aortic stenosis.
Where it's running
-
National cancer institute
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Norma Osama Abdallah Zayed, MD
- Email: norma.osama@nci.cu.edu.eg
- Phone: 01067843111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.