Adding an ultrasound-guided iPACK block to an adductor canal block for pain after knee tumor removal
Analgesic Efficacy of Adding Ultra Sound Guided IPACK Block to Adductor Canal Block for Postoperative Pain Management After Excision of Tumors Around Knee: a Randomized Controlled Trial
This trial will test whether adding an ultrasound-guided iPACK block to an adductor canal block reduces pain and opioid use after surgical removal of tumors around the knee in adults aged 18–65.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | National Cancer Institute, Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07382297 on ClinicalTrials.gov |
What this trial studies
Adults aged 18–65 with ASA physical status II–IV undergoing excision of tumors around the knee under spinal anesthesia are randomly assigned to receive an adductor canal block plus an ultrasound-guided iPACK block or to a control arm without peripheral blocks. The study measures time to first rescue analgesia, postoperative morphine consumption, and pain on the visual analogue scale (VAS). Standard non-opioid analgesics are given per protocol and morphine boluses are used for VAS >4. The intervention is performed under ultrasound guidance at a single center (National Cancer Institute, Cairo).
Who should consider this trial
Good fit: Adults aged 18–65, ASA II–IV, scheduled for excision of tumors around the knee under spinal anesthesia who agree to the study procedures are ideal candidates.
Not a fit: Patients with contraindications such as allergy to local anesthetics, neuromuscular disorders, prior knee surgery or infection, refusal, or contraindications to spinal anesthesia are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the combined ACB+iPACK approach could lower pain scores and opioid needs, helping patients mobilize and recover faster after knee tumor excision.
How similar studies have performed: Prior studies combining ACB and iPACK for other knee procedures have shown improved postoperative pain scores and earlier mobility, though evidence specifically after tumor excision is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stated willingness to comply with all study procedures and availability for the duration of the study * American Society of Anesthesiologists (ASA) physical status II-IV. * Patients undergoing excision of tumors around the knee under spinal anesthesia Exclusion Criteria: * Patient refusal. * Neuromuscular disorders * Allergy to local anesthetics * Previous history of knee surgery * Patients with a prior knee infection * Contraindications to spinal anesthesia as coagulopathies and severe aortic stenosis.
Where this trial is running
Cairo
- National cancer institute — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Norma Osama Abdallah Zayed, MD
- Email: norma.osama@nci.cu.edu.eg
- Phone: 01067843111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.