Condition

Esophagus Cancer clinical trials and research

• 24Clinical trials
• 11Countries

Newest Esophagus Cancer clinical trials

All recruiting trials (24)

• Personalized Ultrafractionated Stereotactic Radiotherapy with Perioperative FLOT for GEJ and Esophageal Cancer

  This trial tests adding a personalized, ultra-fractionated radiotherapy boost (PULSAR) to standard perioperative FLOT chemotherapy for patients with esophageal or gastroesophageal junction cancer to see if it can be used safely.

  Recruiting Phase 1 University of Texas Southwestern Medical Center · Dallas, Texas · NCT07700420

• Preventing nausea and vomiting during multi-cycle chemo and immunotherapy in esophageal and lung cancer

  This study tests a combination antiemetic with dexamethasone to see if it lowers nausea and vomiting in adults with esophageal or lung cancer receiving several cycles of chemo plus immunotherapy.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617246

• Ivonescimab plus FOLFOX for advanced HER2-negative stomach and gastroesophageal junction adenocarcinoma

  This study tests whether adding ivonescimab to standard FOLFOX chemotherapy helps people with advanced, HER2-negative stomach or gastroesophageal junction adenocarcinoma as first-line treatment.

  Recruiting at 2 sites Phase 2 Massachusetts General Hospital · Santa Monica, California and 1 other locations · NCT07070466

• AI prediction of response to pre-surgery chemoimmunotherapy for esophageal cancer

  This project tests whether combining clinical records, CT scans, pathology, and lab results with deep learning can predict which patients with locally advanced esophageal cancer will respond to neoadjuvant chemoimmunotherapy before surgery.

  Recruiting Central South University · Changsha, Hunan · NCT07063901

• 18F-G1 PET/CT to see early immunotherapy response in solid tumors and blood cancers

  We are testing if the 18F-G1 PET/CT scan can help tell early on whether people with solid tumors or blood cancers will respond to immunotherapy.

  Recruiting Peking University First Hospital · Beijing · NCT07039474

• Combining afatinib and palbociclib for previously treated advanced esophageal squamous cell carcinoma

  This trial tests whether taking afatinib together with palbociclib helps control tumor growth in people with recurrent or metastatic esophageal squamous cell carcinoma who have already received prior treatments.

  Recruiting Phase 1/2 West China Hospital · Chengdu, Sichuan · NCT06753747

• Imaging method for digestive system cancer using targeted PET scans

  This study is testing a new type of PET scan to see if it can better help doctors find and diagnose cancers in the digestive system.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06715839

• Nutritional therapy for esophageal cancer patients during surgery

  This study tests if personalized nutritional support during surgery can help malnourished patients with esophageal cancer recover better and avoid complications.

  Recruiting at 17 sites Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality and 16 other locations · NCT06510543

• Treatment for patients with unresectable esophageal cancer

  This study is testing if a new combination of a medication called Tislelizumab with chemotherapy and radiation can help people with advanced esophageal cancer that can't be surgically removed live longer and feel better.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT06430658

• Observational study on chemo-radiotherapy for early-stage esophageal cancer after endoscopic dissection

  This study is testing new treatment plans for patients with high-risk early-stage esophageal cancer after surgery to see if they can improve recovery while reducing side effects.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 1 other locations · NCT06385717

• Using imaging to identify sensitive esophageal cancer for better treatment

  This study is testing if special imaging can help find esophageal cancer that responds well to treatment, so doctors can give more personalized care to patients.

  Recruiting Charite University, Berlin, Germany · Berlin · NCT06189898

• Treatment using CEA-targeted CAR-T cells for advanced solid tumors

  This study is testing a new type of immune therapy using CAR-T cells to see if it can help people with advanced solid tumors that have a specific marker called CEA.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Wuhu, Anhui · NCT06126406

• Targeting CEA with CAR-T cells for advanced solid tumors

  This study is testing a new type of CAR-T cell treatment for people with advanced solid tumors to see if it's safe and how well it works.

  Recruiting at 2 sites Phase 1 Chongqing Precision Biotech Co., Ltd · Hangzhou, Zhejiang and 1 other locations · NCT06043466

• Acupuncture for treating nerve pain caused by chemotherapy in cancer patients

  This study is testing if acupuncture can help cancer patients with nerve pain caused by chemotherapy feel better after stopping their treatment.

  Recruiting at 9 sites GERCOR - Multidisciplinary Oncology Cooperative Group · Amiens and 14 other locations · NCT05850130

• Individualized chemotherapy dosing for gastrointestinal cancer

  This study tests whether giving personalized doses of chemotherapy can help people with advanced gastrointestinal cancers do better with their treatment.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT05780684

• Review of esophageal cancer outcomes at Memorial Sloan Kettering Cancer Center

  This study looks at how the edges of removed tumors affect survival in patients with advanced esophageal cancer after surgery.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT05706558

• CA-4948 combined with chemotherapy and immunotherapy for advanced gastric and esophageal cancer

  This study is testing a new treatment combining CA-4948 with chemotherapy and immunotherapy to see if it helps people with advanced stomach and esophageal cancer who haven't had other treatments yet.

  Recruiting Phase 1 Washington University School of Medicine · St Louis, Missouri · NCT05187182

• Using virtual reality to help manage pain in GI cancer patients

  This study is testing if virtual reality can help people with GI cancer manage their severe abdominal pain better than standard treatments.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT04907643

• Chemoradiotherapy for esophageal and esophagogastric junction cancer

  This study is testing a new combination of chemotherapy, radiation, and immune therapies to see if it helps people with advanced esophageal or esophagogastric junction cancer live longer and feel better.

  Recruiting at 5 sites Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Anyang, Henan and 4 other locations · NCT04821778

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Using MRI and CT to Evaluate Tumor Response in Esophageal Cancer Treatment

  This study tests whether MRI can better track how well treatment is working for people with esophageal cancer compared to regular CT scans.

  Recruiting Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT02988921

• Comparing chemoradiation and surgery for advanced esophageal cancer

  This study is testing whether a combination of chemotherapy and radiation works better than surgery for Chinese patients with advanced esophageal cancer.

  Recruiting at 2 sites The First Affiliated Hospital of Henan University of Science and Technology · Anyang, Henan and 1 other locations · NCT02972372

• Survey for patients with esophageal cancer and upper digestive diseases

  This study is trying to gather information from patients with esophageal cancer and other upper digestive issues to see how they are doing after treatment and improve future care.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT02530983

• Proton therapy for treating esophageal cancer

  This study tests a new treatment for localized esophageal cancer that combines proton therapy with chemotherapy to see if it can work better and cause less harm than traditional methods.

  Recruiting Loma Linda University · Loma Linda, California · NCT01684904

Related topics

Quick answers

How many Esophagus Cancer clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in China (13 trials), United States (9 trials), Germany (2 trials), France (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 4, Phase 2: 3, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →