Sponsor or institution
Clinical trials and research at St. Joseph's Hospital and Medical Center
As of November 12, 2026, Find a Trial lists 39 NIH-funded research projects at this institution, with $94.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 39NIH research projects
NIH-funded research (39)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Access for All in ALS: West Coordinating Center for ALS patient care and research
A national ALS research network is building a West Coast coordinating center to collect and study high-quality patient samples and data to speed better ALS therapies.
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South African Manganese Exposure and Brain Health in a Long-Term Cohort
A study in an African community exposed to manganese pollution aims to understand whether exposure accelerates motor and thinking problems over time, with potential to guide protections for affected residents.
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Brain network problems tied to memory and thinking in adults with Down syndrome
This project looks at why key brain cells and networks that support memory and self-awareness break down in adults with Down syndrome.
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Manganese Pollution and Brain Health in African Communities
This grant studies whether environmental manganese exposure from a large South African smelter is linked to worsening motor and cognitive health in a defined African cohort.
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Access for All in ALS — West Coordinating Center
This project builds a national network to collect clinical data and patient samples to speed development of new treatments for people living with ALS.
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Microglia's role in C9orf72-linked ALS and frontotemporal dementia
This work looks at whether immune cells in the brain called microglia drive nerve-cell and synapse loss in people with C9orf72-related ALS and frontotemporal dementia.
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Manganese pollution and brain health near a South African smelter
This project follows people who live near a South African manganese smelter to learn how exposure affects thinking and movement over time.
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Chronic Lung Transplant Fibrosis: LKB1 in Exosomes and Lung Scarring
A study exploring how tiny particles called exosomes carrying a tumor suppressor protein (LKB1) might influence scarring and long-term failure after lung transplant.
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Multi-parametric perfusion MRI to predict brain cancer therapy response
A study to improve brain cancer care by using advanced MRI techniques to predict early how tumors respond to treatment.
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Unraveling the Causes of White Matter Changes in Aging
A researchers team will use advanced computer methods to understand why white matter changes happen in aging brains, with a focus on Alzheimer’s-related processes and other brain changes.
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How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
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Better MRI Scans for Brain Cancer Treatment
This project aims to make MRI scans more accurate at showing how well brain cancer treatments are working for patients.
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Better brain scans to detect Parkinson’s circuit changes
This project uses advanced brain imaging in lab models to look for clearer signs of Parkinson’s disease that could help people with early or developing symptoms.
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Understanding the causes of white matter changes in aging brains
This study is looking at changes in the brain that can affect memory and thinking in older adults, using advanced technology to find different patterns that might help us understand what causes these changes, so we can create better treatments and prevention strategies for aging individuals.
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Improving access to treatments for ALS patients
This study is working to improve new treatments for ALS by gathering important health information and samples from both patients with symptoms and those without, so we can better understand the disease and help more people across the country.
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Manganese pollution and brain health in South African communities
This project follows people who live near a manganese smelter in South Africa to see how long-term exposure affects movement, thinking, and mood over time.
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Endothelial C3a Receptor's Role in Stroke-Related Brain Injury
Aims to understand how a specific immune signal (C3a receptor on blood vessel lining) worsens brain damage after stroke, with the goal of improving outcomes after clot-busting therapy.
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How brain immune cells (microglia) affect C9orf72-linked ALS and frontotemporal dementia
Researchers are looking at whether brain immune cells called microglia cause synapse loss and thinking or behavior problems in people with C9orf72-linked ALS and frontotemporal dementia.
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Diffusion MRI biomarkers to guide nerve injury repair
A new MRI-based test using diffusion tensor imaging could help doctors decide sooner when to repair damaged peripheral nerves after injury and how well repairs are healing.
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Imaging biomarkers of brain toxicity in welders
This project studies how welding exposure affects brain chemistry and imaging findings related to movement disorders in workers who have metal exposure.
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Understanding Chronic Lung Transplant Problems
This research explores why some lung transplant patients develop a condition called chronic lung allograft dysfunction, or CLAD, which limits how long their new lungs last.
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Understanding how microglia affect ALS and frontotemporal dementia
This study is looking at how a type of brain cell called microglia might affect the progression of ALS and frontotemporal dementia in people with a specific gene mutation, to help us understand how these conditions develop and find new ways to treat them.
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Investigating genetic and imaging factors to improve treatment for brain swelling after traumatic injury
This study is looking to create better, personalized treatments for brain swelling after a head injury by using genetic and imaging information to understand how different factors affect recovery, so it can help people with this condition feel better faster.
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Investigating how aging and cell aging affect the risk of brain aneurysm rupture
This study is looking at how getting older might increase the risk of brain aneurysms bursting and whether getting rid of certain aging cells can help prevent this, with the hope of finding new treatments that could benefit patients at risk.
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Improving MRI techniques to assess brain cancer treatment response
This study is working to make MRI scans better at showing how well treatments for brain cancer are working, so patients can get quicker and more accurate answers without needing more invasive tests like biopsies.
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Investigating brain connectivity changes in models of Parkinson's disease
This study is looking at how Parkinson's disease changes the way different parts of the brain communicate with each other, using special brain scans to find early signs of the disease, and it's designed for people with Parkinson's who want to help improve understanding and treatment of their condition.
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Investigating the neurotoxic effects of manganese exposure in South African communities.
This study is looking at how manganese from the environment affects the brain and movement skills of people living in Meyerton, South Africa, especially those who live near a big smelter, to see how their health compares to those who aren't exposed.
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Investigating how a specific receptor affects brain injury after a stroke.
This study is looking at how a specific receptor in the brain might affect inflammation and damage after a stroke, with the hope of finding new treatments that could help stroke patients recover better.
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Repurposing Siponimod for Alzheimer’s Disease
A patient-friendly look at trying siponimod, a drug approved for other conditions, to see if it can help people living with Alzheimer’s disease.
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Understanding how microglia contribute to ALS and frontotemporal dementia
This study is looking at how certain brain cells called microglia might affect the progression of ALS and frontotemporal dementia in people with a specific genetic mutation, to help us understand how these conditions develop and find new ways to treat them.
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Improving access to ALS clinical trials and treatments
This study is bringing together hospitals and researchers across the U.S. and Puerto Rico to gather important information from people with ALS, so we can speed up the development of better treatments for everyone living with this condition.
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Investigating brain changes in welders exposed to manganese
This study is looking at how being around manganese, which can be harmful to the brain, affects welders' brain health over time, using special brain scans to see if it causes changes similar to those in Parkinson's disease and how it impacts their movement and thinking skills.
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Investigating how Glyburide can help manage brain injuries
This study is looking at how the medication Glyburide might help people with severe brain injuries by preventing their condition from getting worse, and it aims to find out how different patients respond to this treatment so that doctors can provide the best care for each individual.
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Understanding how certain blood cells contribute to the rupture of brain aneurysms
This study is looking at how certain blood cells, called neutrophils and platelets, work together in the brain and might cause bulges in blood vessels, known as aneurysms, to burst, with the hope that understanding this could help improve treatments for patients with this condition.
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Investigating the role of a specific biological pathway in brain aneurysms
This study is looking at how high blood pressure can cause brain aneurysms to burst, which can be very serious, and it aims to find new ways to help prevent this from happening, especially for people with hypertension.
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Using Siponimod to treat Alzheimer's disease
This study is looking at whether Siponimod, a medicine made for multiple sclerosis, can also help people with Alzheimer's by targeting different brain pathways to slow down the disease, and it will keep an eye on how patients' thinking and health change during treatment.
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Investigating brain network issues in individuals with Down syndrome and Alzheimer's disease
This study is looking at how Down syndrome affects the brain and memory, especially since people with Down syndrome are more likely to develop Alzheimer's disease, and it aims to find out what changes happen in the brain that might lead to memory problems.
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Understanding how RNA editing affects TDP-43 movement in cells
This study is looking at how changes in RNA editing affect the movement of a protein called TDP-43, which is connected to diseases like ALS and Alzheimer's, to help find new ways to treat these conditions.
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Investigating brain changes in Lewy Body dementia and Parkinson's disease dementia using patient-derived neurons.
This study is looking at how dementia with Lewy bodies and Parkinson's disease dementia are different by examining brain cells from people who had these conditions, which could help doctors find better ways to diagnose and treat them.
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