Understanding how RNA editing affects TDP-43 movement in cells
Official title: Mechanisms of A-I RNA editing-mediated nuclear export of TDP-43
Funded at St. Joseph's Hospital and Medical Center · NIH-10575984 · Data updated 2026-11-12
This study is looking at how changes in RNA editing affect the movement of a protein called TDP-43, which is connected to diseases like ALS and Alzheimer's, to help find new ways to treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 22, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $345,566 |
| NIH project number | 1R21NS130492-01 |
| Project ID | NIH-10575984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ALS, frontotemporal dementia, or Alzheimer's disease.
✕Less likely to help
Patients with neurodegenerative diseases not associated with TDP-43 pathology may not receive benefit from this research.
What this research studies
This research investigates the role of RNA editing in the movement of TDP-43, a protein linked to neurodegenerative diseases like ALS and Alzheimer's. The study focuses on how changes in RNA editing can influence TDP-43's location within cells, particularly its export from the nucleus to the cytoplasm. By examining these mechanisms, the research aims to uncover potential therapeutic targets that could mitigate the harmful effects of TDP-43 aggregation. Patients may benefit from insights gained into the molecular processes underlying their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases associated with TDP-43.
How similar studies have gone: While the specific approach of targeting RNA editing in TDP-43 pathology is novel, related research has shown promise in understanding TDP-43's role in neurodegenerative diseases.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Sattler, Rita — St. Joseph's Hospital and Medical Center
- Study coordinator: Sattler, Rita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.