Investigating brain connectivity changes in models of Parkinson's disease
Official title: Multi-scale functional connectivity in preclinical models of Parkinson's disease
Funded at St. Joseph's Hospital and Medical Center · NIH-10990551 · Data updated 2026-11-12
This study is looking at how Parkinson's disease changes the way different parts of the brain communicate with each other, using special brain scans to find early signs of the disease, and it's designed for people with Parkinson's who want to help improve understanding and treatment of their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | January 1, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $359,442 |
| NIH project number | 5R01NS124575-04 |
| Project ID | NIH-10990551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing it.
✕Less likely to help
Patients with advanced Parkinson's disease or those with other neurological disorders may not benefit from this research.
What this research studies
This research focuses on understanding how Parkinson's disease affects brain connectivity by using advanced imaging techniques. It aims to identify new biomarkers that can detect early changes in the brain associated with the disease. By employing a specialized type of functional magnetic resonance imaging (fMRI), the study seeks to improve the sensitivity and specificity of brain imaging in Parkinson's patients. The research also incorporates pharmacological and chemogenetic methods to establish a direct relationship between brain activity and imaging signals.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for Parkinson's disease.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study brain disorders, suggesting potential for success in this approach.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Stokes, Ashley M — St. Joseph's Hospital and Medical Center
- Study coordinator: Stokes, Ashley M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.