Investigating how aging and cell aging affect the risk of brain aneurysm rupture
Official title: Roles of aging and cellular senescence in the development of intracranial aneurysm rupture
Funded at St. Joseph's Hospital and Medical Center · NIH-11051893 · Data updated 2026-11-12
This study is looking at how getting older might increase the risk of brain aneurysms bursting and whether getting rid of certain aging cells can help prevent this, with the hope of finding new treatments that could benefit patients at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $596,813 |
| NIH project number | 5R01AG077780-03 |
| Project ID | NIH-11051893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are at increased risk for intracranial aneurysms due to age-related factors.
✕Less likely to help
Patients who are younger and do not have risk factors for aneurysm rupture may not benefit from this research.
What this research studies
This research explores the connection between aging and the risk of intracranial aneurysm rupture, focusing on how biological changes associated with aging can be modified. It aims to identify the role of cellular senescence, a state where cells stop dividing, in promoting inflammation and tissue damage that may lead to aneurysm rupture. By eliminating senescent cells, the study seeks to determine if this can prevent aneurysmal rupture and to identify specific inflammatory profiles associated with this risk. Patients may benefit from potential new therapies that target these aging-related changes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of brain aneurysm rupture in older adults.
How similar studies have gone: Other research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting this approach may be effective.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Hashimoto, Tomoki — St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
Related research
Other NIH-funded projects on the same topics.
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How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
-
Understanding how brain aneurysm walls and shape change over time
This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.
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Predicting brain aneurysm growth with advanced 4D MRI and tensor math
A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.
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Reprogramming blood-vessel lining cells in inherited brain aneurysms
This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.
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How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms
Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.
-
How cells' cleanup of vessel attachments may affect brain aneurysms
This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.