Investigating how aging and cell aging affect the risk of brain aneurysm rupture
Roles of aging and cellular senescence in the development of intracranial aneurysm rupture
['FUNDING_R01'] · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · NIH-11051893
This study is looking at how getting older might increase the risk of brain aneurysms bursting and whether getting rid of certain aging cells can help prevent this, with the hope of finding new treatments that could benefit patients at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER (nih funded) |
| Locations | 1 site (PHOENIX, UNITED STATES) |
| Trial ID | NIH-11051893 on ClinicalTrials.gov |
What this research studies
This research explores the connection between aging and the risk of intracranial aneurysm rupture, focusing on how biological changes associated with aging can be modified. It aims to identify the role of cellular senescence, a state where cells stop dividing, in promoting inflammation and tissue damage that may lead to aneurysm rupture. By eliminating senescent cells, the study seeks to determine if this can prevent aneurysmal rupture and to identify specific inflammatory profiles associated with this risk. Patients may benefit from potential new therapies that target these aging-related changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are at increased risk for intracranial aneurysms due to age-related factors.
Not a fit: Patients who are younger and do not have risk factors for aneurysm rupture may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of brain aneurysm rupture in older adults.
How similar studies have performed: Other research has shown promising results in targeting cellular senescence to improve health outcomes, suggesting this approach may be effective.
Where this research is happening
PHOENIX, UNITED STATES
- ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER — PHOENIX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HASHIMOTO, TOMOKI — ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
- Study coordinator: HASHIMOTO, TOMOKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.