Investigating brain network issues in individuals with Down syndrome and Alzheimer's disease
Default mode network dysfunction in Down Syndrome
['FUNDING_OTHER'] · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · NIH-10635582
This study is looking at how Down syndrome affects the brain and memory, especially since people with Down syndrome are more likely to develop Alzheimer's disease, and it aims to find out what changes happen in the brain that might lead to memory problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER (nih funded) |
| Locations | 1 site (PHOENIX, UNITED STATES) |
| Trial ID | NIH-10635582 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how Down syndrome (DS) affects brain function, particularly in relation to Alzheimer's disease (AD). It aims to explore the cellular and molecular changes in specific brain regions that are crucial for memory and self-awareness. By studying individuals with DS, who are at high risk for developing dementia, the research seeks to uncover the mechanisms behind cognitive decline. The approach includes analyzing brain tissue to identify differences in neuron health and gene expression between those with and without dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those in midlife or older who may be experiencing cognitive decline.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for dementia in individuals with Down syndrome and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding dementia mechanisms in similar populations, indicating that this approach could yield valuable insights.
Where this research is happening
PHOENIX, UNITED STATES
- ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER — PHOENIX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUFSON, ELLIOTT JAY — ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
- Study coordinator: MUFSON, ELLIOTT JAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome