Investigating genetic and imaging factors to improve treatment for brain swelling after traumatic injury
Official title: A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain Injury
Funded at St. Joseph's Hospital and Medical Center · NIH-11079636 · Data updated 2026-11-12
This study is looking to create better, personalized treatments for brain swelling after a head injury by using genetic and imaging information to understand how different factors affect recovery, so it can help people with this condition feel better faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | May 5, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $552,243 |
| NIH project number | 5R01NS115815-05 |
| Project ID | NIH-11079636 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are exhibiting symptoms of cerebral edema.
✕Less likely to help
Patients with mild brain injuries or those who do not exhibit cerebral edema may not benefit from this research.
What this research studies
This research aims to bridge the gap between laboratory findings and clinical treatments for cerebral edema, a serious condition following traumatic brain injury (TBI). By examining individual genetic and imaging data, the study seeks to develop personalized treatment strategies that target specific pathways involved in brain swelling. The approach includes evaluating the role of the Sur1-Trpm4 pathway and how variations in genetics and protein levels affect patient outcomes. Ultimately, the goal is to enhance the effectiveness of therapies and reduce the burden of cerebral edema management.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for patients suffering from cerebral edema after traumatic brain injury.
How similar studies have gone: Previous research has shown promising results in targeting the Sur1-Trpm4 pathway, indicating potential for success in this novel approach.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Jha, Ruchira Menka — St. Joseph's Hospital and Medical Center
- Study coordinator: Jha, Ruchira Menka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.