Investigating the role of a specific biological pathway in brain aneurysms
Official title: EGF-ADAM17 axis in the pathophysiology of intracranial aneurysm
Funded at St. Joseph's Hospital and Medical Center · NIH-10686891 · Data updated 2026-11-12
This study is looking at how high blood pressure can cause brain aneurysms to burst, which can be very serious, and it aims to find new ways to help prevent this from happening, especially for people with hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 30, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $439,103 |
| NIH project number | 5R01NS109382-05 |
| Project ID | NIH-10686891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with intracranial aneurysms, particularly those with a history of hypertension.
✕Less likely to help
Patients without intracranial aneurysms or those not affected by hypertension may not benefit from this research.
What this research studies
This research focuses on understanding how hypertension contributes to the rupture of intracranial aneurysms, which can lead to severe complications like subarachnoid hemorrhage. The study combines expertise in aneurysm research and cardiovascular diseases to explore the mechanisms involved in this process. By examining the role of angiotensin II and its effects on vascular inflammation and remodeling, the researchers aim to identify potential therapeutic targets. Patients may benefit from insights that could lead to improved prevention strategies for aneurysm rupture.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the rupture of brain aneurysms in patients with hypertension.
How similar studies have gone: Previous research has indicated potential links between the renin-angiotensin system and aneurysm rupture, suggesting that this approach may yield valuable insights.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Hashimoto, Tomoki — St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
Related research
Other NIH-funded projects on the same topics.
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Understanding how brain aneurysm walls and shape change over time
This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.
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Predicting brain aneurysm growth with advanced 4D MRI and tensor math
A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.
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How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
-
Reprogramming blood-vessel lining cells in inherited brain aneurysms
This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.
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How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms
Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.
-
How cells' cleanup of vessel attachments may affect brain aneurysms
This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.