Investigating the role of a specific biological pathway in brain aneurysms
EGF-ADAM17 axis in the pathophysiology of intracranial aneurysm
This study is looking at how high blood pressure can cause brain aneurysms to burst, which can be very serious, and it aims to find new ways to help prevent this from happening, especially for people with hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-10686891 on NIH RePORTER |
What this research studies
This research focuses on understanding how hypertension contributes to the rupture of intracranial aneurysms, which can lead to severe complications like subarachnoid hemorrhage. The study combines expertise in aneurysm research and cardiovascular diseases to explore the mechanisms involved in this process. By examining the role of angiotensin II and its effects on vascular inflammation and remodeling, the researchers aim to identify potential therapeutic targets. Patients may benefit from insights that could lead to improved prevention strategies for aneurysm rupture.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with intracranial aneurysms, particularly those with a history of hypertension.
Not a fit: Patients without intracranial aneurysms or those not affected by hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the rupture of brain aneurysms in patients with hypertension.
How similar studies have performed: Previous research has indicated potential links between the renin-angiotensin system and aneurysm rupture, suggesting that this approach may yield valuable insights.
Where this research is happening
Phoenix, United States
- St. Joseph's Hospital and Medical Center — Phoenix, United States (Active)
Researchers
- Principal investigator: Hashimoto, Tomoki — St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.