Investigating how a specific receptor affects brain injury after a stroke.
Official title: Endothelial complement C3a receptor mediated cerebral injury in a murine stroke model.
Funded at St. Joseph's Hospital and Medical Center · NIH-10943805 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain might affect inflammation and damage after a stroke, with the hope of finding new treatments that could help stroke patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $853,135 |
| NIH project number | 1R01NS138528-01 |
| Project ID | NIH-10943805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced a stroke and are undergoing treatment with tissue plasminogen activator (tPA).
✕Less likely to help
Patients who have not experienced a stroke or those with chronic neurological conditions unrelated to acute brain injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of the complement C3a receptor in brain injury following a stroke. It aims to explore how this receptor contributes to inflammation and damage in the brain after ischemic events. By using a murine model, the study will assess the effects of inhibiting this receptor on brain function and recovery. The ultimate goal is to develop therapies that could improve outcomes for stroke patients by protecting the brain from secondary injuries.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce disability in stroke patients.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for neuroprotection in stroke models, indicating potential for success in this approach.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Ducruet, Andrew Frederick — St. Joseph's Hospital and Medical Center
- Study coordinator: Ducruet, Andrew Frederick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.