Understanding how microglia contribute to ALS and frontotemporal dementia
Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD
This study is looking at how certain brain cells called microglia might affect the progression of ALS and frontotemporal dementia in people with a specific genetic mutation, to help us understand how these conditions develop and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-10897724 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of immune cell in the brain, in the development of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), particularly in patients with the C9orf72 genetic mutation. The study aims to understand how microglia activation correlates with cognitive decline and FTD-like symptoms in ALS patients. By examining brain tissue from affected individuals, researchers will explore the differences in microglial function based on genetic factors and how these cells interact with neurons. This could lead to insights into the mechanisms of disease progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS or FTD, particularly those with the C9orf72 genetic mutation.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to ALS or FTD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target microglial dysfunction, potentially improving outcomes for patients with ALS and FTD.
How similar studies have performed: Previous research has shown that targeting microglial activation can have beneficial effects in other neurodegenerative diseases, suggesting potential for success in this area as well.
Where this research is happening
Phoenix, United States
- St. Joseph's Hospital and Medical Center — Phoenix, United States (Active)
Researchers
- Principal investigator: Sattler, Rita — St. Joseph's Hospital and Medical Center
- Study coordinator: Sattler, Rita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.