Understanding how certain blood cells contribute to the rupture of brain aneurysms
Mechanisms for intracranial aneurysm rupture
This study is looking at how certain blood cells, called neutrophils and platelets, work together in the brain and might cause bulges in blood vessels, known as aneurysms, to burst, with the hope that understanding this could help improve treatments for patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project ID | NIH-10747874 on NIH RePORTER |
What this research studies
This research investigates the roles of neutrophils and platelets in the rupture of intracranial aneurysms, which are bulges in blood vessels in the brain. The study aims to uncover the mechanisms by which these blood cells interact and potentially lead to aneurysm rupture. By examining the formation of Neutrophil Extracellular Traps (NETs) and their relationship with platelets, the research seeks to identify key factors that contribute to vascular damage. Patients may benefit from insights gained into the biological processes involved in aneurysm rupture, which could inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with intracranial aneurysms or those at high risk for developing them.
Not a fit: Patients who do not have intracranial aneurysms or related vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches to prevent the rupture of brain aneurysms, potentially saving lives.
How similar studies have performed: While the specific mechanisms of neutrophils and platelets in aneurysm rupture are not fully understood, related research has shown success in understanding vascular inflammation and its implications in other diseases.
Where this research is happening
Phoenix, United States
- St. Joseph's Hospital and Medical Center — Phoenix, United States (Active)
Researchers
- Principal investigator: Hashimoto, Tomoki — St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.