Understanding how certain blood cells contribute to the rupture of brain aneurysms
Official title: Mechanisms for intracranial aneurysm rupture
Funded at St. Joseph's Hospital and Medical Center · NIH-10747874 · Data updated 2026-11-12
This study is looking at how certain blood cells, called neutrophils and platelets, work together in the brain and might cause bulges in blood vessels, known as aneurysms, to burst, with the hope that understanding this could help improve treatments for patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $375,712 |
| NIH project number | 5R01NS109584-05 |
| Project ID | NIH-10747874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with intracranial aneurysms or those at high risk for developing them.
✕Less likely to help
Patients who do not have intracranial aneurysms or related vascular conditions may not benefit from this research.
What this research studies
This research investigates the roles of neutrophils and platelets in the rupture of intracranial aneurysms, which are bulges in blood vessels in the brain. The study aims to uncover the mechanisms by which these blood cells interact and potentially lead to aneurysm rupture. By examining the formation of Neutrophil Extracellular Traps (NETs) and their relationship with platelets, the research seeks to identify key factors that contribute to vascular damage. Patients may benefit from insights gained into the biological processes involved in aneurysm rupture, which could inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches to prevent the rupture of brain aneurysms, potentially saving lives.
How similar studies have gone: While the specific mechanisms of neutrophils and platelets in aneurysm rupture are not fully understood, related research has shown success in understanding vascular inflammation and its implications in other diseases.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Hashimoto, Tomoki — St. Joseph's Hospital and Medical Center
- Study coordinator: Hashimoto, Tomoki
Related research
Other NIH-funded projects on the same topics.
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Understanding how brain aneurysm walls and shape change over time
This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.
-
Predicting brain aneurysm growth with advanced 4D MRI and tensor math
A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.
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How aging and aged (senescent) cells may cause brain aneurysm rupture
This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.
-
Reprogramming blood-vessel lining cells in inherited brain aneurysms
This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.
-
How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms
Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.
-
How cells' cleanup of vessel attachments may affect brain aneurysms
This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.