Investigating how Glyburide can help manage brain injuries
Official title: A Single Cell and Proteomic Precision Medicine Approach to Glyburide Responsive Contusion Expansion in Severe Traumatic Brain Injury
Funded at St. Joseph's Hospital and Medical Center · NIH-10820416 · Data updated 2026-11-12
This study is looking at how the medication Glyburide might help people with severe brain injuries by preventing their condition from getting worse, and it aims to find out how different patients respond to this treatment so that doctors can provide the best care for each individual.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Joseph's Hospital and Medical Center NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $227,588 |
| NIH project number | 5R21NS131689-02 |
| Project ID | NIH-10820416 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced severe traumatic brain injuries with contusions.
✕Less likely to help
Patients with mild brain injuries or those who do not have contusions may not benefit from this research.
What this research studies
This research focuses on understanding how Glyburide, a medication, can be used to prevent the worsening of brain injuries caused by contusions in patients with severe traumatic brain injury (TBI). By analyzing individual patient data at the molecular and cellular levels, the study aims to identify specific factors that influence how patients respond to Glyburide. This personalized approach seeks to improve treatment outcomes by tailoring therapies to the unique characteristics of each patient's injury. The research will involve advanced techniques such as single-cell analysis and proteomics to gather detailed insights into the mechanisms of contusion expansion.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with severe traumatic brain injuries, potentially reducing morbidity and mortality associated with contusion expansion.
How similar studies have gone: While there has been some preliminary success in using Glyburide for similar conditions, this approach is innovative and aims to fill significant gaps in current treatment strategies.
Where this research is happening
-
St. Joseph's Hospital and Medical Center
Phoenix, United States Active
Researchers
- Principal investigator: Jha, Ruchira Menka — St. Joseph's Hospital and Medical Center
- Study coordinator: Jha, Ruchira Menka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.