Understanding the causes of white matter changes in aging brains
An Integrative Computational Multimodal approach to disentangle Pathophysiologic Heterogeneity of age-related White Matter Hyperintensities
['FUNDING_R01'] · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · NIH-11232282
This study is looking at changes in the brain that can affect memory and thinking in older adults, using advanced technology to find different patterns that might help us understand what causes these changes, so we can create better treatments and prevention strategies for aging individuals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER (nih funded) |
| Locations | 1 site (PHOENIX, UNITED STATES) |
| Trial ID | NIH-11232282 on ClinicalTrials.gov |
What this research studies
This research investigates white matter hyperintensities (WMH), which are changes in the brain that can lead to cognitive decline and dementia in older adults. By using advanced machine learning techniques on MRI data, the study aims to identify different patterns of WMH that may arise from various underlying causes, including Alzheimer's disease and other factors. The goal is to better understand these patterns to develop targeted therapies and prevention strategies for aging individuals. This approach seeks to address the complexity of brain health by moving beyond traditional assessment methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or at risk for dementia.
Not a fit: Patients who are younger or do not exhibit any signs of cognitive decline or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for cognitive decline and dementia in older adults.
How similar studies have performed: Previous research has shown promise in using machine learning to analyze brain imaging data, indicating that this approach could yield valuable insights into WMH pathology.
Where this research is happening
PHOENIX, UNITED STATES
- ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER — PHOENIX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHUAH, CHIA-LING — ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
- Study coordinator: PHUAH, CHIA-LING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.