Sponsor or institution
Clinical trials and research at Mayo Clinic Jacksonville
As of November 12, 2026, Find a Trial lists 178 NIH-funded research projects at this institution, with $174.8 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 178NIH research projects
NIH-funded research (newest 40 of 178)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Carotid artery treatment for people with artery narrowing who don’t have symptoms
A large, international study is testing whether intensive medical care plus either carotid surgery or carotid stenting improves outcomes for people with high-grade carotid artery narrowing who have not yet had symptoms.
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Antibiotic Allergy: Types, Triggers, and How they Work
This grant aims to better understand why certain antibiotics trigger immediate allergic reactions and how to improve testing and diagnosis for patients with suspected antibiotic allergies.
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Lipid-gene Profiles in Septic ARDS
A Mayo Clinic team is studying how dysfunctional HDL in sepsis relates to different ARDS patient outcomes, aiming to find features that could guide better treatment.
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APOE4 and brain lymphatic drainage in Alzheimer's disease
This NIH grant investigates how the APOE4 gene affects the brain’s lymphatic system and its role in Alzheimer’s disease, with potential implications for people at risk.
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Tumor Susceptibility Gene 101: a microglial therapy approach to protect memory in Alzheimer’s disease
A Mayo Clinic team is studying a protein called TSG101 in brain immune cells to slow or prevent cognitive decline in Alzheimer’s disease.
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ABCA7 loss of function and Alzheimer's disease
This grant examines how changes in ABCA7, a brain lipid transporter, may influence Alzheimer's disease risk and progression in people.
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Radiation Therapy Innovation to Improve Lymphoma Trials and Carbon Ion Research Path
A Mayo Clinic-led effort to better design and run lymphoma trials by integrating advanced radiation therapy and exploring carbon ion radiotherapy.
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Brain cell–derived EV markers to differentiate Alzheimer’s and related dementias
A Mayo Clinic team is testing brain-cell–specific tiny particles in blood to tell apart Alzheimer’s disease and similar dementias using advanced machine-learning analysis.
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Mobile mindfulness app to help spinal cord injury patients manage chronic pain
A widely available mindfulness app is being tested to help people with spinal cord injury reduce chronic pain and improve mood and daily functioning.
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Pain AI at Home: Personalizing Pain Care with Wearable Sensors
A Mayo Clinic team is building an at-home, AI-powered system that uses wearable sensors to measure pain and tailor pain medications for adults.
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UFM1's role in tau pathology and Alzheimer’s disease, explored with innovative gene tools
A Mayo Clinic team will study how UFM1 affects tau buildup in Alzheimer’s and related tau diseases, using new CRISPR methods to see if changing UFMylation can protect brain cells.
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Genetic modifiers of APOE-related Alzheimer’s risk and microglial function
A Mayo Clinic team is studying why APOE gene variants affect Alzheimer's risk by looking for genetic modifiers and how they change brain immune cell behavior.
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APOE variants and Alzheimer's disease pathways in humans
Scientists are studying how different APOE gene variants influence Alzheimer's disease pathology and risk, with potential to inform personalized approaches for people at risk.
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APOE protective variants and Alzheimer’s risk – molecular insights
This NIH grant looks at how certain APOE gene variants that seem to protect against Alzheimer’s may shape the protein and its interactions, giving clues for future therapies.
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Bioinformatics, Biostatistics, and Data Management Core for Alzheimer’s Aging Research
A dedicated core will manage and analyze complex multi-omics and cognitive data to uncover how APOE-related aging processes contribute to Alzheimer’s-related cognitive decline.
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Multi-omics core to study APOE-related Alzheimer’s disease resilience
A Mayo Clinic Jacksonville team is developing advanced protein and lipid analysis tools to understand why some people with Alzheimer’s disease remain more resilient, using human tissues, organoids, and models.
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Human iPSC Core: using stem cells to study how APOE changes Alzheimer’s risk
Researchers at Mayo Clinic in Jacksonville are using patient-derived stem cells to understand how different APOE genetic variants affect Alzheimer’s disease risk and progression.
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Human Biospecimen Core to study APOE-related protection in Alzheimer’s disease
A specialized repository will collect and share human brain tissue, CSF, and blood to help researchers understand how APOE genes and rare protective variants reduce Alzheimer’s risk.
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Administrative Core for APOE and Alzheimer's disease research consortium
A large, multi-project NIH program is led from Mayo Clinic Jacksonville to keep the entire APOE- and Alzheimer’s-focused research organized, compliant, and Collaborative.
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APOE variants and Alzheimer’s disease: uncovering protective mechanisms
A large NIH-funded effort at Mayo Clinic Jacksonville is studying how different forms of APOE may protect against Alzheimer’s disease and age-related memory problems, with the goal of guiding new therapies.
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Expanded access to ibudilast for ALS patients through a networked care program
ALS patients could gain access to the experimental drug ibudilast through a coordinated program that connects doctors, home visits, and easy online consent and monitoring.
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Standardizing Behavioral and Social Research in Alzheimer’s through Ontology-Based Approaches
A Mayo Clinic team is building an organized way to study how daily behaviors and social factors affect Alzheimer’s and related dementias to improve care and caregiver support.
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Understanding tau protein clusters in Alzheimer's disease in the brain
Researchers are studying the tangled tau protein networks in people with Alzheimer's disease to uncover how these clusters form and spread, which could point toward new ways to help patients.
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Connecting Patient Populations to Clinical Trials for Better Cancer Care
A national program at Mayo Clinic Jacksonville aims to help more people with cancer join clinical trials by improving outreach, education, and data coordination.
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A Digital Portal Connecting Cancer Patients to Clinical Trials
A Mayo Clinic project uses an AI-powered virtual assistant to help adults find and refer themselves to cancer clinical trials.
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Mayo Clinic outreach to engage Black and Hispanic adults in Alzheimer’s and related dementia research in Jacksonville
This project builds local outreach and research programs to include more Black/African American and Hispanic/Latino adults in Alzheimer’s and related dementia studies.
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Local chemotherapy implant to attack aggressive meningiomas
A Mayo Clinic team is testing a bioresorbable implant that locally delivers chemotherapy to aggressive meningiomas to help prevent recurrence.
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Understanding how heart injury leads to scarring and heart failure
This grant studies how a protein called Neuropilin-1 shapes heart scarring after a heart attack, with the goal of finding new ways to prevent heart failure.
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Advanced informatics for simulating Alzheimer's disease clinical trials
A Mayo Clinic Jacksonville team is building smarter, data-driven ways to model Alzheimer’s trials using real-world patient data to help design better studies.
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Better tests for cephalosporin (a common antibiotic) allergy
This project tries new ways to tell whether someone who says they're allergic to cephalosporin antibiotics truly has a risky allergy.
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Understanding how bladder and breast cancers evolve over time to improve diagnosis and treatment
A Mayo Clinic team is developing computer models of how bladder and breast cancers change and progress, using large sets of tissue samples to map the cancer’s journey.
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C9orf72-related brain changes in frontotemporal dementia and ALS
This NIH grant funds research to understand how a genetic change in C9orf72 affects brain regions in frontotemporal dementia and ALS, with the goal of identifying clues that could help patients in the future.
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Antibiotic Allergy: Understanding Why Some Reactions Happen and How We Can Detect Them
A Mayo Clinic team will study why certain antibiotics trigger dangerous allergy reactions and look for better ways to detect and understand these reactions.
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Targeted, selective inhibition of trypsin-like enzymes to study and treat disease
Researchers are developing new, highly selective ways to block specific trypsin-like enzymes to better understand their roles in diseases and potentially guide safer therapies.
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Multi-omic signatures of ALS-spectrum disorders (ALS)
Researchers will study the genetic and molecular changes in brain tissue from people with ALS and related conditions to understand why motor neurons die.
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Understanding C9orf72 repeat length and methylation in ALS and FTD
A Mayo Clinic team is studying the DNA repeat that causes ALS and FTD to learn how its size and chemical marks relate to disease features.
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Glioblastoma: tackling drug resistance to mitotic inhibitors in the brain
This project looks at glioblastoma and tests ways to overcome resistance to drugs that disrupt cell division, with a focus on delivering treatments directly to the brain.
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Th17-inducing vaccine plus pembrolizumab for recurrent ovarian cancer
A phase I/II study tests a vaccine that activates Th17 immune cells together with pembrolizumab to help fight recurrent ovarian cancer.
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Plaque shape clues to better choosing carotid treatment
Researchers are studying carotid plaque features to help decide when revascularization will most safely prevent strokes in people with high-grade carotid narrowing.
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Looking inside the inflamed pancreas with live imaging
Researchers are testing whether blocking blood-clotting signals and an enzyme called trypsin can reduce damage in acute pancreatitis using advanced live imaging in mice.
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