Plaque shape clues to better choosing carotid treatment
Official title: Plaque morphologic characteristics that affect prevention of stroke by carotid revascularization
Funded at Mayo Clinic Jacksonville · NIH-11337818 · Data updated 2026-11-12
Researchers are studying carotid plaque features to help decide when revascularization will most safely prevent strokes in people with high-grade carotid narrowing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | May 13, 2026 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $442,086 |
| NIH project number | 1R01NS147997-01 |
| Project ID | NIH-11337818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with high-grade asymptomatic carotid stenosis enrolled in CREST-2 or similar cohorts who have undergone baseline carotid ultrasound and plaque imaging.
✕Less likely to help
Patients without carotid stenosis or without available imaging data from CREST-2 may not benefit.
What this research studies
This project uses existing clinical data from large trials to analyze ultrasound images and plaque shapes collected before treatment. By applying standardized image analysis, the study aims to link plaque morphology with stroke risks after either surgery or stenting. The goal is to improve patient selection and personalize decisions about revascularization in the context of modern medical risk management.
Why it matters
Potential benefit: If successful, doctors could better identify which patients would benefit most from revascularization, reducing stroke risk and procedure-related harms.
How similar studies have gone: Previous work within CREST-2 has created a foundation for linking plaque features to outcomes, with ongoing analyses enhancing predictive value.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Meschia, James F — Mayo Clinic Jacksonville
- Study coordinator: Meschia, James F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.