Understanding tau protein clusters in Alzheimer's disease in the brain
Official title: Capturing the molecular complexity of tau pathology-associated proteomes involved in the etiology of Alzheimer's disease and related dementias
Funded at Mayo Clinic Jacksonville · NIH-11399151 · Data updated 2026-11-12
Researchers are studying the tangled tau protein networks in people with Alzheimer's disease to uncover how these clusters form and spread, which could point toward new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $732,167 |
| NIH project number | 5R01AG076122-03 |
| Project ID | NIH-11399151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with Alzheimer’s disease or related tauopathies who donate brain tissue or participate through observational samples.
✕Less likely to help
People without Alzheimer’s disease or related tauopathies would not directly benefit from this project.
What this research studies
This project uses advanced proximity-proteomics to map the neighborhood of tau-related proteins inside the brains of people affected by Alzheimer’s disease and related tauopathies. By examining how these proteins interact, accumulate, and influence brain cells, researchers aim to reveal mechanisms behind disease progression. The study addresses technical challenges in profiling insoluble protein aggregates to identify potential targets for treatment. The work is conducted at Mayo Clinic Jacksonville by Dr. Wilfried Rossoll and team, focusing on human disease biology to guide future therapies.
Why it matters
Potential benefit: If successful, the research could identify new protein targets for therapies that slow or block tau-driven neurodegeneration.
How similar studies have gone: Previous studies have linked tau networks to disease progression, but this project seeks deeper molecular mapping to uncover new targets.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Rossoll, Wilfried — Mayo Clinic Jacksonville
- Study coordinator: Rossoll, Wilfried
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.