Pain AI at Home: Personalizing Pain Care with Wearable Sensors
Official title: Development of the PAIN (Pain AI iNtervention) Platform for Patients at Home
Funded at Mayo Clinic Jacksonville · NIH-11424404 · Data updated 2026-11-12
A Mayo Clinic team is building an at-home, AI-powered system that uses wearable sensors to measure pain and tailor pain medications for adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 15, 2026 |
| Project end | September 14, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,277,111 |
| NIH project number | 1R01DA066583-01 |
| Project ID | NIH-11424404 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with pain who can wear sensors and participate in at-home monitoring.
✕Less likely to help
Individuals unable to use wearable sensors or participate in continuous monitoring may not benefit.
What this research studies
This project aims to turn continuous physiological signals from wearable sensors into an at-home pain biomarker using advanced deep learning. The system would monitor data like heart rate, respiration, HRV, movement, temperature, and more to create personalized pain treatment recommendations in real time. By developing a closed-loop AI that interprets physiologic patterns associated with pain, patients could receive safer, more precise pain management without constant clinic visits.
Why it matters
Potential benefit: If successful, patients could receive more accurate pain relief while reducing the risk of over- or under-medication.
How similar studies have gone: Previous work shows promise in using physiological signals for pain cues, but this is a next-step in real-time home-based AI-enabled pain management.
Where this research is happening
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Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Forte, Antonio Jorge — Mayo Clinic Jacksonville
- Study coordinator: Forte, Antonio Jorge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.