Understanding how heart injury leads to scarring and heart failure
Official title: Distinct Pathways of VPF/VEGF Receptors
Funded at Mayo Clinic Jacksonville · NIH-11378311 · Data updated 2026-11-12
This grant studies how a protein called Neuropilin-1 shapes heart scarring after a heart attack, with the goal of finding new ways to prevent heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | December 8, 2017 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $635,762 |
| NIH project number | 5R01HL140411-07 |
| Project ID | NIH-11378311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this basic science grant; however, findings may eventually benefit adults with a history of heart attack.
✕Less likely to help
People seeking immediate clinical interventions or those without access to advanced research settings may not directly benefit.
What this research studies
Researchers at Mayo Clinic Jacksonville are exploring how Neuropilin-1 influences the pathways that drive fibrosis after myocardial infarction. They will use mouse models with cell-type specific knockdown of NRP1 and analyze changes in gene expression to identify targets for therapy. The work includes advanced sequencing to map how different heart cells respond and how microRNAs relate to heart failure genes. The ultimate aim is to uncover mechanisms that could be targeted to reduce scarring and preserve heart function after injury.
Why it matters
Potential benefit: If successful, the research could lead to new treatments that lessen heart tissue scarring and prevent heart failure after a heart attack.
How similar studies have gone: Previous work has linked Neuropilin-1 to heart injury responses, with emerging evidence suggesting tissue-specific roles that could guide therapies.
Where this research is happening
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Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Mukhopadhyay, Debabrata — Mayo Clinic Jacksonville
- Study coordinator: Mukhopadhyay, Debabrata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.