APOE variants and Alzheimer's disease pathways in humans
Official title: Project 2 (APOE protective variants and Alzheimer's disease pathologies)
Funded at Mayo Clinic Jacksonville · NIH-11418803 · Data updated 2026-11-12
Scientists are studying how different APOE gene variants influence Alzheimer's disease pathology and risk, with potential to inform personalized approaches for people at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $454,090 |
| NIH project number | 2U19AG069701-06 |
| Project ID | NIH-11418803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer's disease or at risk due to APOE genotype and related pathology.
✕Less likely to help
People without Alzheimer's disease or without APOE-related risk factors may not directly benefit.
What this research studies
This project looks at how APOE gene variants affect the buildup of amyloid plaques and tau tangles, and how these changes relate to brain cell activity and neurodegeneration. Using data from Mayo Clinic, researchers connect genetic risk with brain changes in Alzheimer's disease to understand why some people develop disease earlier or more severely. The study focuses on how APOE4 increases risk while APOE2 may be protective, and how this impacts Aβ and tau interactions. Results could guide future strategies to predict risk and tailor interventions for individuals with different APOE profiles.
Why it matters
Potential benefit: Understanding APOE-related pathways could pave the way for personalized risk assessment and targeted therapies for Alzheimer's disease.
How similar studies have gone: Prior work shows APOE genotype influences amyloid and tau pathology; this study builds on that foundation to connect genetic risk with brain changes.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Holtzman, David M. — Mayo Clinic Jacksonville
- Study coordinator: Holtzman, David M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.