Bioinformatics, Biostatistics, and Data Management Core for Alzheimer’s Aging Research
Official title: Core E (Bioinformatics, Biostatistics, and Data Management Core)
Funded at Mayo Clinic Jacksonville · NIH-11418801 · Data updated 2026-11-12
A dedicated core will manage and analyze complex multi-omics and cognitive data to uncover how APOE-related aging processes contribute to Alzheimer’s-related cognitive decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $591,116 |
| NIH project number | 2U19AG069701-06 |
| Project ID | NIH-11418801 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at risk for or living with age-related cognitive decline or Alzheimer’s disease dementia who may contribute data or samples through related studies.
✕Less likely to help
This core does not directly recruit patients; benefits depend on downstream translational findings.
What this research studies
This grant funds Core E to coordinate study design, data quality, and analytics for a multi-center U19 program focused on aging, APOE, and cognitive loss. It will integrate multi-omics, genotypic, and phenotypic data using advanced machine learning and deep learning to uncover aging mechanisms. The core also handles data/resource management and supports manuscripts, ensuring rigorous, reproducible analyses that bridge projects within the program.
Why it matters
Potential benefit: If successful, patients may benefit from a clearer understanding of molecular pathways behind age-related cognitive decline and Alzheimer’s, informing future therapies and personalized care.
How similar studies have gone: Similar multi-omics integration efforts have yielded new insights into aging and Alzheimer’s, though integration challenges remain.
Where this research is happening
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Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Ren, Yingxue — Mayo Clinic Jacksonville
- Study coordinator: Ren, Yingxue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.