Antibiotic Allergy: Understanding Why Some Reactions Happen and How We Can Detect Them
Official title: Antibiotic Allergy: Phenotypes, Endotypes, and Mechanisms
Funded at Mayo Clinic Jacksonville · NIH-11365846 · Data updated 2026-11-12
A Mayo Clinic team will study why certain antibiotics trigger dangerous allergy reactions and look for better ways to detect and understand these reactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | July 3, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $322,792 |
| NIH project number | 5UG3AI190113-03 |
| Project ID | NIH-11365846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with suspected or confirmed antibiotic allergies, especially penicillin and related drugs.
✕Less likely to help
Individuals without a history of antibiotic allergy or those without suspected immune-mediated reactions may not benefit directly.
What this research studies
This project looks at how people react to common antibiotics and why some experiences lead to immediate, severe responses like anaphylaxis. Researchers will combine clinical data and lab insights to map the immune mechanisms behind penicillin and other antibiotic allergies. The goal is to identify specific markers and pathways that explain why certain drugs cause reactions in some patients. The study builds on existing knowledge to improve testing, diagnosis, and potentially safer antibiotic use for those with suspected allergies.
Why it matters
Potential benefit: If successful, this work could lead to more accurate allergy tests and safer antibiotic choices for patients.
How similar studies have gone: Prior work shows partial understanding for penicillin allergy, but many antibiotics lack clear mechanisms or reliable tests.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Blumenthal, Kimberly G. — Mayo Clinic Jacksonville
- Study coordinator: Blumenthal, Kimberly G.
Related research
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Understanding antibiotic allergy to improve care for patients
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.