Antibiotic Allergy: Types, Triggers, and How they Work
Official title: Antibiotic Allergy: Phenotypes, Endotypes, and Mechanisms
Funded at Mayo Clinic Jacksonville · NIH-11592359 · Data updated 2026-11-12
This grant aims to better understand why certain antibiotics trigger immediate allergic reactions and how to improve testing and diagnosis for patients with suspected antibiotic allergies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | July 3, 2025 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $135,626 |
| NIH project number | 3UG3AI190113-03S1 |
| Project ID | NIH-11592359 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with suspected immediate antibiotic allergies, especially to penicillin and related drugs, who may benefit from improved testing or risk assessment.
✕Less likely to help
Individuals without suspected antibiotic allergies or those not undergoing allergy testing or biomarker research may see limited direct benefit.
What this research studies
The project focuses on improving knowledge about how immediate antibiotic allergies occur, including penicillin and other drugs like cephalosporins and sulfonamides. It will use clinical data and translational immunology approaches to identify antigenic determinants and biomarkers, addressing gaps in current testing. The work builds on prior research to refine phenotypes and causality assessments so clinicians can better predict who is at risk and how to manage reactions. Results could lead to more accurate tests and safer antibiotic choices for patients who need these medications.
Why it matters
Potential benefit: If successful, patients may receive more accurate allergy testing and safer antibiotic options, reducing unnecessary avoidance and severe reactions.
How similar studies have gone: Previous work suggests that antibiotic allergy mechanisms are diverse and not fully understood, with some testing improving accuracy but gaps remain.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Blumenthal, Kimberly G. — Mayo Clinic Jacksonville
- Study coordinator: Blumenthal, Kimberly G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.