Human iPSC Core: using stem cells to study how APOE changes Alzheimer’s risk
Official title: Core C (Human iPSC Core)
Funded at Mayo Clinic Jacksonville · NIH-11418799 · Data updated 2026-11-12
Researchers at Mayo Clinic in Jacksonville are using patient-derived stem cells to understand how different APOE genetic variants affect Alzheimer’s disease risk and progression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $611,601 |
| NIH project number | 2U19AG069701-06 |
| Project ID | NIH-11418799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who carry APOE ε4, ε3, or ε2 alleles and have available iPSC-derived samples or consented to contribute them.
✕Less likely to help
Individuals without APOE variants or who are not participating in iPSC-based projects may not directly benefit.
What this research studies
This grant supports a centralized iPSC core that creates and edits stem cell lines from people with different APOE genotypes. Scientists differentiate these iPSCs into brain cell types and organoids to study how APOE variants influence disease pathways both within cells and through interactions with other cells. The goal is to uncover mechanisms that make some variants protective and to identify targets for new treatments. The core builds on existing iPSC resources and expert differentiation to provide high-quality lines and cells for researchers. The work is designed to translate cellular findings into therapies that could reduce Alzheimer’s risk or delay onset for patients and at-risk individuals.
Why it matters
Potential benefit: If successful, findings could lead to new therapeutic strategies that mitigate Alzheimer’s risk in people with certain APOE variants.
How similar studies have gone: Previous work has shown APOE variant effects on AD pathways; this project extends a proven iPSC approach to study protective variants.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Karch, Celeste Marie — Mayo Clinic Jacksonville
- Study coordinator: Karch, Celeste Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.