Understanding how bladder and breast cancers evolve over time to improve diagnosis and treatment
Official title: Disease Progression Modeling of Bladder Cancer
Funded at Mayo Clinic Jacksonville · NIH-11370519 · Data updated 2026-11-12
A Mayo Clinic team is developing computer models of how bladder and breast cancers change and progress, using large sets of tissue samples to map the cancer’s journey.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $501,455 |
| NIH project number | 5R01CA266113-04 |
| Project ID | NIH-11370519 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with bladder cancer or breast cancer whose tissue samples could contribute to understanding cancer progression.
✕Less likely to help
Direct clinical benefits may be limited for individuals whose samples are not included or whose cancer follows uncommon trajectories.
What this research studies
This grant funds a computational project that analyzes many cancer tissue samples to build models of how bladder and breast cancers develop and progress. By creating pseudo-time trajectories from static samples, the researchers aim to reveal patterns that could inform better diagnostics, prognostics, and targeted therapies. The work emphasizes noninvasive insights from existing tissues, with a focus on how genetic and epigenetic changes interact with the tumor environment. Outcomes could guide personalized care and help identify critical points where treatment could be most effective.
Why it matters
Potential benefit: If successful, the project could lead to more accurate predictions of cancer progression and better, personalized treatment strategies.
How similar studies have gone: Previous work with CancerMapp and similar time-series-inspired analyses have shown meaningful insights from large tissue-sample datasets.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Goodison, Steve — Mayo Clinic Jacksonville
- Study coordinator: Goodison, Steve
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.