Multi-omics core to study APOE-related Alzheimer’s disease resilience
Official title: Core D (Multi-Omics Core)
Funded at Mayo Clinic Jacksonville · NIH-11418800 · Data updated 2026-11-12
A Mayo Clinic Jacksonville team is developing advanced protein and lipid analysis tools to understand why some people with Alzheimer’s disease remain more resilient, using human tissues, organoids, and models.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $552,008 |
| NIH project number | 2U19AG069701-06 |
| Project ID | NIH-11418800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease or related cognitive impairment whose tissues or samples could be studied, including those contributing to organoid or model studies.
✕Less likely to help
Patients whose disease subtype or biology does not involve APOE-mediated pathways may not directly benefit from these findings.
What this research studies
This project uses cutting-edge proteomics and lipidomics with spatial and single-cell resolution to map molecules involved in APOE-related resilience in Alzheimer’s disease. Researchers will integrate mass spectrometry with transcriptomics to identify DNA, RNA, protein, and lipid changes directly in human tissues, organoids, and animal/cell models. The work aims to reveal how complex cellular pathways contribute to disease heterogeneity and resilience, informing potential targets for therapy. It involves a multidisciplinary team experienced in neurodegeneration and large-scale omics data analysis to push the boundaries of what we can measure in AD tissue.
Why it matters
Potential benefit: If successful, the work could identify new molecular targets and biomarkers linked to resilience in Alzheimer’s disease, guiding future therapies and personalized approaches.
How similar studies have gone: Previous omics-focused studies in neurodegeneration have shown that integrated proteomics and lipidomics can reveal important disease mechanisms, but single-cell spatial approaches in APOE-related resilience are still emerging.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Peng, Junmin — Mayo Clinic Jacksonville
- Study coordinator: Peng, Junmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.