Understanding how RNA guides wound healing and regeneration in adults
Official title: Investigation of how RNA-directed feedback loops coordinate wound healing and regeneration
Funded at Ut Southwestern Medical Center · NIH-11393845 · Data updated 2026-11-12
This NIH grant explores how RNA-related signals coordinate healing and tissue repair in adults who have wounds or injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $441,400 |
| NIH project number | 5R35GM160161-02 |
| Project ID | NIH-11393845 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with normal or impaired wound healing who could provide tissue samples or participate in related studies.
✕Less likely to help
People without wound healing issues or those unavailable for tissue sampling may not benefit directly.
What this research studies
The project looks at how RNA processing proteins and their target RNAs control how cells move and repair tissues after injury. It uses mammalian models to study the timing and location of cell migration during wound healing and how this links to regenerative processes. The goal is to map the RNA-based regulatory loops that ensure proper healing without excessive scarring, with a focus on adult biology.
Why it matters
Potential benefit: If successful, this work could inform new therapies to improve wound healing and tissue regeneration in adults.
How similar studies have gone: Previous studies in model organisms suggest RNA-based timing mechanisms influence tissue repair, but translation to mammals requires confirmation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Osborne, Jihan K. — Ut Southwestern Medical Center
- Study coordinator: Osborne, Jihan K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.