Neutrophil diversity and flexibility in healing burn injuries
Official title: Neutrophil heterogeneity and plasticity in wound healing
Funded at University of Wisconsin-Madison · NIH-11357664 · Data updated 2026-11-12
A study exploring how different neutrophil types behave during burn wound healing and whether blood neutrophils can signal how well a wound will recover.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $375,430 |
| NIH project number | 5R35GM150893-04 |
| Project ID | NIH-11357664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with burn injuries who are admitted for care and consent to participate in serial blood and tissue sample collection.
✕Less likely to help
Patients with minor burns or those unable to provide consent may not directly benefit.
What this research studies
This project looks at neutrophils, a key part of our immune system, and how their diverse states change as a burn wound heals. By combining high-dimensional and single-cell profiling with bioinformatics, researchers aim to map the neutrophil landscape in burn tissue and in the blood. The goal is to see if blood neutrophils can predict complications or outcomes, potentially guiding more personalized wound care. The work will involve analyzing patient samples over time to understand how neutrophil functions relate to healing progress.
Why it matters
Potential benefit: If successful, it could lead to blood-based markers that predict healing outcomes and inform targeted therapies to improve burn wound recovery.
How similar studies have gone: Other studies have shown neutrophil diversity influences tissue repair, but the specific link to burn healing and blood-based prediction is still developing.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Dinh, Huy Quang — University of Wisconsin-Madison
- Study coordinator: Dinh, Huy Quang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.