Curcumin topical spray for healing after a first molar extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind, three-arm clinical trial examines the effect of a Curcuma longa–based topical spray on early wound healing and postoperative symptoms after mandibular first molar extraction. Participants are assigned to curcumin spray, 0.12% chlorhexidine spray, or standard care, applied twice daily for seven days. Outcomes include pain scores, wound healing indices, and measurements of wound dimensions, with salivary inflammatory biomarkers (IL-1β, TNF-α, PGE2) analyzed to gauge local inflammation during recovery. Follow-up assessments occur on postoperative days 1, 3, 5, 7, and 14. The study is conducted at Istanbul University and aims to determine if curcumin offers clinically meaningful benefits over standard care or chlorhexidine in the early healing phase.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy individuals aged 18-40 years with ASA physical status I.
* Patients scheduled for extraction of a mandibular first molar.
* Individuals who voluntarily agree to participate and provide written informed consent.
* Individuals without chronic systemic disease and who do not use regular medication.
* Patients with no oral health condition that would contraindicate the surgical procedure.

Exclusion Criteria:

* Pregnant or breastfeeding individuals.
* Patients with systemic diseases or immunosuppression.
* Individuals with a history of previous surgery or trauma in the same region.
* Individuals with a known allergy or hypersensitivity to turmeric (curcumin), chlorhexidine spray, or any component of the study products.
* Individuals who smoke or consume alcohol.
* Individuals who regularly use medications, particularly anti-inflammatory or anticoagulant drugs.

Where it's running

• Istanbul University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery
  Istanbul, Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Metin Berk Kasapoglu, associate professor — Istanbul University
• Study coordinator: Ece Duru
• Email: duru.ece@ogr.iu.edu.tr
• Phone: +905314066610

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.