Jaw ridge changes after tooth removal and ridge preservation
Official title: Determinants of Bone Dimensional Changes After Extraction and Alveolar Ridge Preservation
Run by Marquette University · NCT06624982 · Data updated 2026-11-12
We will see if a socket that widens right after a tooth is removed or stays the same changes ridge width and height four months later in adults having a single extraction with bone graft and a resorbable membrane.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Marquette University Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Status | Recruiting |
| Started | October 8, 2025 |
| Main results expected | October 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | November 17, 2025 |
| Trial ID | NCT06624982 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 in generally good health with controlled periodontal disease who are scheduled for a single tooth extraction with bone graft and resorbable membrane, have adjacent teeth, and maintain adequate socket wall integrity.
✕Probably not a fit
Smokers, pregnant people, individuals with active periodontal disease, systemic conditions that impair healing, or sites with major pre-existing bone loss or severe infection are unlikely to benefit from these specific findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll adults scheduled for a single tooth extraction with immediate bone grafting and a resorbable membrane at Marquette University's Graduate Periodontics Clinic. Investigators will record clinical and anatomic measures before extraction, immediately after extraction, and at a four-month follow-up, including buccolingual ridge width and height, gingival width and thickness, and buccal bone thickness. Detailed extraction variables (number of roots, root size, instruments used, flap elevation, extraction duration, anesthetic, and operator experience) will also be recorded to identify factors tied to dimensional changes. The main comparison is between sites that show immediate post-extraction socket expansion versus those that show no width change to determine their relationship with four-month bone and ridge outcomes.
Why it matters
Potential benefit: If successful, the findings could help dentists predict how the ridge will heal and tailor grafting and implant planning to improve long-term outcomes.
How similar studies have gone: Prior studies show alveolar ridge preservation can limit post-extraction bone loss, but using immediate post-extraction socket expansion versus no change as a determinant of later dimensional changes is less well studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (18-75 years) * Good general health (controlled conditions) * Controlled periodontal disease * Scheduled for single tooth extraction with bone graft placement and resorbable membrane * Tooth to be extracted must have adjacent teeth * Socket wall integrity Exclusion Criteria: * Smoking * Pregnancy * Active periodontal disease * Systemic conditions that affect healing * Lack of socket wall integrity (bone loss ≥50 %) prior to extraction, teeth with severe infection requiring pre-extraction antibiotic treatment to control infection), and contraindications for tooth extraction.
Where it's running
-
Marquette University School of Dentistry Graduate Periodontics Clinic
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Vrisiis Kofina, DDS, MS — Marquette University
- Study coordinator: Vrisiis Kofina, DDS, MS
- Email: vrisiis.kofina@marquette.edu
- Phone: 4142886521
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.