Early Wound Healing and Outcomes of Regenerative Periodontal Surgery
Official title: Influence of Early Wound Healing on the 12-month Clinical and Radiographic Outcomes of Regenerative Periodontal Surgery: a Prospective Observational Cohort Study
Run by University of Roma La Sapienza · NCT07683962 · Data updated 2026-11-12
This study looks to see if healing in the first 1–2 weeks after periodontal regenerative surgery can predict how well the treatment works at 12 months in people with advanced periodontitis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Roma La Sapienza Academic / other |
| Locations | 1 site (Rome, Rome) |
| Status | Recruiting |
| Started | July 2026 |
| Main results expected | October 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | July 31, 2026 |
| Trial ID | NCT07683962 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with Stage III–IV periodontitis and at least one deep infrabony defect (PPD ≥ 6 mm, radiographic depth ≥ 3 mm) who have good oral hygiene at the time of surgery.
✕Probably not a fit
Patients with poor general health, heavy smoking, or uncontrolled systemic conditions may not experience benefit from regenerative outcomes.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, prospective observational cohort study in adults with Stage III–IV periodontitis undergoing regenerative periodontal therapy. It tests whether early wound healing at 1 and 2 weeks relates to 12‑month clinical and radiographic outcomes. It also seeks to identify patient-, site-, and technique-related factors that are associated with better early wound healing. Data will include intrabony defect characteristics, flap design, and biomaterial use to understand predictors of healing success.
Why it matters
Potential benefit: If successful, findings could help clinicians predict longer-term outcomes from early healing and tailor techniques to improve regenerative success.
How similar studies have gone: Previous related work suggests early healing patterns influence regenerative outcomes, but this study adds specific site- and technique-related factors in a prospective design.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Stage III or IV Periodontitis. * Presence of at least one deep interproximal infrabony defect (Probing Pocket Depth \[PPD\] \>= 6 mm, radiographic depth \>= 3 mm). * Optimal oral hygiene: Full-Mouth Plaque Score (FMPS) and Full-Mouth Bleeding Score (FMBS) \< 15% at the time of surgery. Exclusion Criteria: * Systemic: ASA III-VI classification; uncontrolled diabetes; medications causing gingival overgrowth (e.g., nifedipine, cyclosporine, phenytoin); heavy smokers (\>10 cigarettes/day); pregnancy or lactation. * Local: Third molars; Grade III tooth mobility; inadequate endodontic treatment; teeth undergoing orthodontic treatment; teeth supporting removable or implant-linked fixed prosthetics.
Where it's running
-
Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology
Rome, Rome, Italy Recruiting
Study contacts
- Study coordinator: Andrea Pilloni
- Email: andrea.pilloni@uniroma1.it
- Phone: +39 3356409374
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.