CD74 and Mucosal Wound Healing
Official title: CD74 and Wound Healing
Funded at University of Florida · NIH-11370161 · Data updated 2026-11-12
A study at the University of Florida looks at how the CD74 protein helps mucosal healing after injuries like surgery or infection, aiming to find ways to improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 16, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $337,829 |
| NIH project number | 5R01DK131313-06 |
| Project ID | NIH-11370161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with mucosal injuries or those undergoing procedures that disrupt the mucosal barrier who could participate in future translational work, genetics analyses, or related studies.
✕Less likely to help
Some participants may not directly benefit if their involvement is limited to tissue samples or basic mechanistic studies without immediate therapeutic implications.
What this research studies
This project explores how the CD74 receptor and its partner MIF influence the healing of damaged mucosal tissue, such as the lining of the gut. Researchers will investigate what controls CD74 expression, whether activating CD74 can safely speed healing, and how human genetic differences affect CD74 activity. The work combines laboratory studies to uncover mechanisms with analyses that could point to new therapeutic approaches for faster mucosal repair. The findings could inform future treatments to support patients recovering from procedures or inflammatory conditions that disrupt the mucosal barrier.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to promote faster and safer mucosal wound healing in patients.
How similar studies have gone: Prior work has shown CD74 signaling plays a role in mucosal repair, supporting potential benefits of this line of investigation.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Moonah, Shannon — University of Florida
- Study coordinator: Moonah, Shannon
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.