Effects of different CO2 and 1565 nm fractional laser doses on forearm skin healing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, self-controlled observational study in about 20 healthy Chinese female volunteers who receive both an ablative CO2 fractional laser and a non-ablative 1565 nm fractional laser on contralateral inner forearms. Each laser is applied to four separate test sites using different energy/density parameter sets to create a dose–response matrix. Skin responses are followed from baseline through immediate post-treatment and multiple early timepoints up to 10 days using clinical scoring (edema, erythema), standardized photography, high-frequency ultrasound, and objective instruments measuring color, melanin/hemoglobin, and barrier function (TEWL). The design focuses on dynamic, early wound and barrier changes after different laser intensities rather than therapeutic outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female Chinese study participants aged 18 to 60 years (inclusive).
* Fitzpatrick skin phototypes III, IV, or V.
* Willing to receive non-ablative fractional laser (M22) and ablative fractional laser (CO2) irradiation on the test sites during the study.
* No primary or secondary lesions (such as scars, ulcers, vesicles, tattoos) on the test sites.
* Has not participated in any other studies involving the test area (forearms) in the past 2 months.
* Agrees not to use skin-whitening products on the test area during the study period.
* In good general health at the time of the study.
* Volunteers to participate and signs the informed consent form and photo release authorization.
* Willing to comply with all requirements of the study.

Exclusion Criteria:

* Study participants with skin diseases or skin allergies in the test area.
* Presence of moderate to severe inflammatory skin diseases (e.g., active eczema, acute photosensitive dermatitis, etc.) on the test sites within the past 4 weeks, or those who require treatment with oral or topical corticosteroids or immunosuppressants for skin conditions.
* On the day of the visit, the investigator judges the presence of significant diffuse erythema, desquamation, or exudation in the test area that may significantly affect skin color measurement.
* The investigator assesses that the participant is currently suffering from a stable or progressively worsening disease.
* Participant is planning for pregnancy, is pregnant, or is breastfeeding (applicable to female participants only).
* Participant with immunodeficiency.
* Participant has a history of photosensitivity or photoallergy.
* Participant has a history of skin cancer or malignant melanoma.
* Presence of significant scars, tattoos, surgical incisions, or pigmented lesions (e.g., prominent birthmarks) in the test area that may affect assessment, and in the investigator's judgment, would impede normal imaging or scoring.
* Has used high-potency active products containing high concentrations of retinoic acid/retinol, alpha hydroxy acids, salicylic acid, etc., on the test area frequently (≥3 times per week) for an extended period (≥4 weeks) within the past 3 months, which, in the investigator's judgment, may significantly affect skin texture or barrier status.
* History of moderate to severe sun exposure (e.g., prolonged outdoor work, travel to seaside/high altitude) within the past 4 weeks, resulting in significant tanning or sunburn in the test area that, in the investigator's judgment, may interfere with study-related readings.
* Participation in other clinical or consumer testing projects involving the skin condition of the test area within the past 4 weeks.
* Presence of significant mental or cognitive impairment affecting compliance, and the investigator considers the participant unable to understand the study procedures or complete the tests as required.

Where it's running

• Shanghai China-norm Quality Technical Service Co., Ltd.
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Yanwen Jiang
• Email: jiangyanwen@china-norm.com
• Phone: 13501700841

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lactoferrin Gel for Healing and Implant Stability in Immediate Mandibular Molars

  A 4% bovine lactoferrin nanohydrogel is being tested to see if it helps soft tissue and bone heal better and improve implant stability after immediate mandibular molar implants.

  Recruiting Phase 2/3 Future University in Egypt · Cairo, Cairo Governorate · NCT07889674

• Curcumin topical spray for healing after a first molar extraction

  This study tests whether a curcumin spray applied to the extraction site helps healing and reduces pain compared with chlorhexidine spray or standard care in healthy adults undergoing a first molar extraction.

  Recruiting Istanbul University · Istanbul, Istanbul · NCT07874789

• Calcaneal Bone Marrow Cells in Foot/Ankle Surgery Patients

  This observational study tests whether routine preoperative blood tests relate to the quality and behavior of mesenchymal stem cells from calcaneal bone marrow in adults undergoing foot or ankle surgery.

  Recruiting Universidade Sao Francisco · Bragança Paulista, São Paulo · NCT07802106

• Obesity and normal-weight healing after gum graft surgery using collagen plug or PRF

  This study tests whether healing after a gum graft differs by weight class (obese vs. normal weight) and compares platelet-rich fibrin clot to the standard collagen plug.

  Recruiting University of Iowa · Iowa City, Iowa · NCT07756112

• Early Wound Healing and Outcomes of Regenerative Periodontal Surgery

  This study looks to see if healing in the first 1–2 weeks after periodontal regenerative surgery can predict how well the treatment works at 12 months in people with advanced periodontitis.

  Recruiting University of Roma La Sapienza · Rome, Rome · NCT07683962

• Ozoaqua scar care after open abdominal surgery compared with standard care

  This study tests if adding Ozoaqua products after open abdominal surgery improves the scar quality at 3 months compared with usual care.

  Recruiting at 2 sites Laboratorios Ozoaqua · Pamplona, Navarre and 1 other locations · NCT07678372

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.