How genetic factors related to GLP-1 affect appetite and weight gain in children
Official title: Associations of GLP-1-related genotypes with appetitive traits, food cue reactivity, and prospective weight gain in pre-adolescence
Funded at Dartmouth College · NIH-10997768 · Data updated 2026-11-12
This study is looking at how certain genes related to a hormone that helps control hunger might affect how kids aged 9-12 eat and respond to food, to better understand their risk of gaining weight.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $53,774 |
| NIH project number | 1F30DK138711-01A1 |
| Project ID | NIH-10997768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 9-12 years who may be at risk for obesity due to genetic factors.
✕Less likely to help
Patients outside the age range of 9-12 years or those without genetic predispositions to obesity may not benefit from this research.
What this research studies
This research investigates the relationship between genetic variants associated with GLP-1, a hormone that regulates appetite, and various eating behaviors in children aged 9-12. By analyzing genetic data and appetitive traits in a sample of 312 children, the study aims to understand how these genetic factors may influence responses to food cues and contribute to weight gain. The approach combines genetic analysis with behavioral assessments to explore the potential links between genetics and obesity risk in pediatric populations.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for obesity in children, potentially informing targeted interventions.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of obesity and appetite regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Renier, Timothy J — Dartmouth College
- Study coordinator: Renier, Timothy J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.