Impact of e-cigarettes during pregnancy on children's health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of e-cigarette use during pregnancy on the health outcomes of children. It aims to gather data on pregnant women who smoke, vape, or are dual users, and follow their children for two years postnatally. The study will assess various health parameters, including respiratory diseases and developmental issues, to understand the long-term implications of e-cigarette exposure in utero. The research is motivated by the rising popularity of e-cigarettes and the need for more evidence regarding their safety compared to traditional tobacco smoking.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women aged 18 or greater and less than 46 years of age at booking
* Pregnant with a singleton fetus
* Smokers (exhaled CO reading of greater than or equal to 4) or
* Self-reported vaper or
* Dual user (smoker/vaper)
* Non-smokers
* Able to understand and read English.
* Willing to agree to follow-up for the two-year duration of the study in the postnatal period (ie. unlikely to move out of the catchment area).

Exclusion Criteria:

* Women pregnant with twins or higher order multiples
* Late bookers - defined as booking after 24+0 weeks' gestational age
* Fetus or infant diagnosed with a major congenital abnormality (major structural abnormality, ie congenital diaphragmatic hernia (CDH), omphalocele, major cardiac defects ie. which require immediate admission to NICU +/- transfer to cardiology for surgery, chromosomal abnormalities, syndromes - Turner's/Noonan's) or a lethal fetal anomaly
* Any inherited disorder of metabolism or Cystic Fibrosis on Guthrie Card/ neonatal blood spot screening
* History of significant medical disorder in pregnancy e.g. cardiac, haematological, or endocrine disease (including gestational diabetes requiring insulin)
* Significant maternal psychiatric disorder, e.g. delusional or psychotic disorders, severe depression requiring hospitalisation, use of \>1 psychotropic drugs for treatment
* Serious co-morbid addiction issues e.g. opiate abuse, methadone maintenance program
* Severe intellectual disability or lack of capacity

Where it's running

• Rotunda Hospital
  Dublin, Ireland Recruiting
• National Maternity Hospital, Holles Street
  Dublin, Ireland Recruiting
• Coombe Womens Hospital
  Dublin, Ireland Recruiting

Study contacts

• Principal investigator: Des Cox, MB BCh BAO — University College Dublin
• Study coordinator: Des W Cox, MB BCh BAO
• Email: desmond.cox@ucd.ie
• Phone: +35314282638

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Prenatal education to reduce environmental exposures during pregnancy

  Aimed at pregnant people, this program tests whether a classroom-style education can help reduce exposure to harmful pollutants from seafood and nearby pollution sources.

  Recruiting at 2 sites The University of Texas Medical Branch, Galveston · Galveston, Texas and 1 other locations · NCT07758114

• Interprofessional Training to Improve Care for Peri-Delivery Patients with Substance Use Disorder

  This program tests INSPIRE, a set of online and in-person trainings for healthcare teams to reduce stigma and improve care for people with substance use disorder around labor, delivery, and postpartum at the University of Utah.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07707115

• Lower-extremity blood pressure monitoring during cesarean under spinal anesthesia

  This study tests whether noninvasive blood pressure monitoring from the toe is better than the arm at predicting neonatal outcomes during cesarean delivery with spinal anesthesia.

  Recruiting Ohio State University · Columbus, Ohio · NCT07685730

• Care4mommies: a compassion-based approach to support moms-to-be

  A compassion-based program with pregnancy-specific content is being tested to see if it helps pregnant people build self-compassion and strengthen the bond with their baby.

  Recruiting Portucalense University · Porto, Porto District · NCT07611175

• Eating more eggs during pregnancy to support fetal brain development

  This test will see if pregnant women who eat 10–14 eggs per week have better fetal brain development than those who follow a general healthy prenatal diet.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07583186

• TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping

  This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.

  Recruiting University of Zurich · Zurich · NCT07568483

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.