Understanding how vaping THC with or without nicotine affects how it works in the body
Official title: Assessing pharmacokinetic and pharmacodynamic variability of Δ9-tetrahydrocannabinol delivered from vaping products with and without concurrent use of nicotine
Funded at Roswell Park Cancer Institute Corp · NIH-11365055 · Data updated 2026-11-12
This study looks at how smoking-vape devices deliver THC and how adding nicotine changes how THC acts in the body and its effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $635,648 |
| NIH project number | 5R01DA057228-05 |
| Project ID | NIH-11365055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who currently use THC-containing vaping liquids, with or without nicotine, and are willing to participate in real-world and laboratory PK/PD assessments.
✕Less likely to help
Individuals who do not use cannabis vaping products or nicotine-containing vapes are unlikely to benefit from these results.
What this research studies
Researchers will study how device type, liquids, and user vaping habits influence how THC enters and leaves the body, using real-world participants and a mobile lab. They will compare THC exposure and effects when nicotine is not used versus when it is, and will also run a controlled lab test to see if the same amount of THC behaves differently in those conditions. Participants will vape their own legal THC cartridges with their usual devices, while investigators measure outcomes in a real-life setting and in a controlled environment. This work builds on nicotine vaping methods to understand THC PK/PD more clearly, in people who actually vape cannabis products.
Why it matters
Potential benefit: If successful, the findings could inform safer vaping practices and regulatory decisions regarding THC and nicotine co-use.
How similar studies have gone: Previous nicotine-vaping PK/PD research informs this approach, but THC vaping PK/PD is less well established and this study tests a similar design with cannabis.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Smith, Danielle — Roswell Park Cancer Institute Corp
- Study coordinator: Smith, Danielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.