Lung health in Canadians who use vaping devices

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The CLOUD program is a pan-Canadian, multicentre, longitudinal effort that applies advanced imaging, novel pulmonary function tests, dynamic exercise testing, and airway cell sequencing to characterize vaping-related lung changes. It enrolls adolescents (12–18) and adults (19+) across user groups including never-users, exclusive e-cigarette users, exclusive cigarette smokers, and dual users. Participants undergo baseline and follow-up physiologic testing, imaging, exercise testing, and specimen collection to look specifically for small-airway injury. The study aims to define early signs of lung damage from vaping and improve detection across the lifespan.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adolescent arm:

* Aged ≥12 and \<19 years old
* Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively

Adult arm:

* Aged ≥19 years old
* Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently

Exclusion Criteria:

Adolescent arm:

* Contraindication to pulmonary function testing and cardiopulmonary exercise testing
* Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
* Have smoked combustible cigarettes within the last 6 months
* Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)
* Inability to provide written informed consent

Adult arm:

* Contraindication to pulmonary function testing and cardiopulmonary exercise testing
* Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of \>1 joint-year
* Currently undergoing treatment for lung cancer
* Inability to provide written informed consent

No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.

Where it's running

• University of Alberta (Clinical Sciences Building)
  Edmonton, Alberta, Canada Recruiting
• BC Cancer Agency
  Vancouver, British Columbia, Canada Recruiting
• BC Children's Hospital Research Institute
  Vancouver, British Columbia, Canada Recruiting
• St. Paul's Hospital
  Vancouver, British Columbia, Canada Recruiting
• University of Ottawa (The Ottawa Hospital General Campus)
  Ottawa, Ontario, Canada Recruiting
• McMaster University (Research Institute of St. Joe's Hamilton)
  Hamilton, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Janice Leung, MD — University of British Columbia
• Study coordinator: Janice Leung, MD
• Email: janice.leung@hli.ubc.ca
• Phone: 604-836-0423

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Social media support groups to help teens and young adults quit vaping

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  Recruiting University of California, San Francisco · San Francisco, California · NCT07540780

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• Parents Helping Parents for Youth Vaping Cessation

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• E-cigarette Cessation for Hispanic/Latino Teens in Florida

  This project tests a six-session, CBT-based e-cigarette cessation program tailored for Hispanic/Latino high school students to see if it helps reduce vaping use.

  Recruiting Florida International University · Miami, Florida · NCT07192601

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.