Condition

Subjective Cognitive Decline clinical trials and research

• 12Clinical trials
• 8NIH research projects
• 7Countries

Newest Subjective Cognitive Decline clinical trials

All recruiting trials (12)

• Blood tests using plasma biomarkers to diagnose and track Alzheimer’s disease

  A large, year-long study in Milan is testing whether blood markers can help diagnose Alzheimer’s and predict how it will progress in people with memory concerns.

  Recruiting IRCCS San Raffaele · Milan, Milano · NCT07717567

• Predicting cognitive test scores from narrated stories using AI

  We will test whether an AI program can estimate standard cognitive test scores from short recorded storytelling tasks in people aged 50 and older with memory or thinking concerns.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07511270

• Chinese Classics recitation training for people with subjective memory concerns

  A 6-month program of Chinese Classics recitation is being tested to see if it helps people aged 60+ who notice memory problems but don’t have measurable impairment.

  Recruiting China Medical University Hospital · Taichung · NCT07463391

• Exergame combined physical-and-cognitive training for 50–60-year-olds with subjective memory decline in China

  This pilot will test whether an exercise video game that combines physical and thinking tasks can improve movement, thinking, and doing both at once in Chinese adults aged 50–60 who notice memory decline.

  Recruiting The Hong Kong Polytechnic University · Chengdu, Sichuan · NCT07085663

• Home-based brain monitoring to assess cognitive decline in older adults

  This study is testing a new home kit that tracks brain activity and sleep in older adults to see if it can help spot signs of cognitive decline.

  Recruiting Bitbrain · Zaragoza, Zaragoza · NCT06993207

• Validation of a questionnaire for cognitive decline in German

  This study is testing a new questionnaire in German to see if it can help people undergoing dementia tests understand their own memory changes and how those changes relate to Alzheimer's disease.

  Recruiting Ludwig-Maximilians - University of Munich · München, Bavaria · NCT06711952

• Early diagnosis and intervention for cognitive dysfunction in diabetes patients

  This study is trying to find early signs of thinking problems in people over 45 with Type 2 diabetes to help them get better care.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06650969

• Identifying early signs of Alzheimer's disease using advanced imaging and biomarker analysis

  This study is trying to find early signs of Alzheimer's disease in people who are at risk, using advanced brain scans and blood tests to help with earlier diagnosis and treatment.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06561906

• Effects of social isolation and interaction on dementia risk in people with subjective cognitive decline

  This study is trying to see how being socially isolated or interacting with others affects the risk of dementia in people who notice early signs of memory problems.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, China, Jiangsu · NCT06335836

• Using deep brain stimulation and cognitive training to improve memory in older adults with cognitive decline

  This study is testing whether a combination of brain stimulation and memory training can help older adults with early signs of memory problems improve their thinking skills.

  Recruiting Rotman Research Institute at Baycrest · Toronto, Ontario · NCT06095063

• How attention and cholinergic signaling work in older adults with subjective cognitive decline

  This project will test whether blocking a key brain chemical with mecamylamine disrupts attention more in older adults who feel their thinking is slipping than in those who do not, using cognitive tests and EEG.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06002477

• Understanding cognitive decline and mild cognitive impairment in Alzheimer's disease

  This study looks at how people with different levels of memory issues, including those with Alzheimer's, feel about their cognitive decline to better understand how it progresses.

  Recruiting Barcelonabeta Brain Research Center, Pasqual Maragall Foundation · Barcelona, Catalonia · NCT03851523

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Predicting Early Dementia Risk from Health Records Using AI

  A plan to use big health records and smart computer methods to spot people who may be in the early stages of memory decline before dementia

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11399877

• Tracing early memory concerns and outcomes using health records and AI

  Researchers are using electronic health records and artificial intelligence to find adults with early memory worries and identify who may later develop dementia.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11176369

• Understanding early signs of cognitive decline using health records and AI

  This study is looking at how electronic health records can help spot early signs of memory problems that might lead to Alzheimer's and similar conditions, so we can find people who need support before they get a formal diagnosis.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11121163

• Creating an online mindfulness program for adults experiencing cognitive decline

  This study is testing an online mindfulness program to help adults who feel their thinking skills are slipping, with the hope that it can improve their focus and possibly benefit their brain health, while also comparing it to a group learning about healthy lifestyles.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11063290

• Understanding cognitive decline in older Hispanics/Latinos

  This study is looking at how older Hispanic and Latino individuals feel about their thinking skills and how those feelings connect to actual changes in their memory and thinking, with the goal of spotting early signs of Alzheimer's disease to help with better diagnosis and care.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11012375

• Investigating how sleep and physical frailty affect cognitive decline in older adults

  This study is looking at how sleep problems and physical weakness in older adults with early signs of memory issues might affect their thinking skills and risk of developing dementia, with the goal of finding ways to help them stay mentally sharp longer.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10973042

• Understanding early cognitive changes in Alzheimer's disease

  This study is looking at how people notice changes in their thinking skills, especially in the early stages of Alzheimer's, and it’s for anyone who has concerns about their memory; you'll share your thoughts on your cognitive abilities every few months using a device, and the researchers will compare what you say with

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10762473

• Effects of Baduanjin exercise on memory and cognitive decline in older adults

  This study is looking at whether practicing Baduanjin, a gentle exercise routine, can help older adults who feel like their memory is slipping but haven't been diagnosed with serious problems, by improving their memory and brain function.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10688181

Related topics

Quick answers

How many Subjective Cognitive Decline clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (4 trials), Taiwan (2 trials), Spain (2 trials), Italy (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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