Investigating how sleep and physical frailty affect cognitive decline in older adults
Cognitive progression among older adults with subjective cognitive decline and mild cognitive impairment: the roles of sleep and physical frailty
This study is looking at how sleep problems and physical weakness in older adults with early signs of memory issues might affect their thinking skills and risk of developing dementia, with the goal of finding ways to help them stay mentally sharp longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10973042 on NIH RePORTER |
What this research studies
This research focuses on older adults experiencing subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to understand how sleep disturbances and physical frailty contribute to the progression of cognitive decline towards dementia. The study will analyze the relationship between these factors and the presence of Alzheimer’s disease biomarkers, aiming to identify how they interact and influence each other. By examining these connections, the research seeks to uncover potential interventions that could slow down cognitive deterioration in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are experiencing subjective cognitive decline or mild cognitive impairment.
Not a fit: Patients who do not have subjective cognitive decline or mild cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or delaying the onset of dementia in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the links between sleep, physical frailty, and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Huang, Jing — Johns Hopkins University
- Study coordinator: Huang, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.