Chinese Classics recitation training for people with subjective memory concerns

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, assessor-blinded trial will enroll 60 adults 60 years or older with subjective cognitive decline and randomly assign them to the recitation training or a non-active control for six months. Participants will undergo neuropsychological testing, plus multimodal brain and biological assessments (fMRI, EEG, blood biomarkers, gut microbiota, and fecal metabolomics) at baseline, after the intervention, and during annual follow-ups. The goal is to understand potential brain and biological changes associated with this culturally tailored memory-training approach. Results will help determine whether this training can slow or alter early cognitive concerns and what biomarkers may reflect any effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 60 years old
* At least two "yes" responses to the following questions are required:

  1. Forgetting where things are placed?
  2. Unable to recall the names of good friends?
  3. Unable to follow and recall conversation?
  4. Subjective memory problems?
  5. Consider own memory to be worse than others of a similar age?

Exclusion Criteria:

* Objective cognitive impairment defined as ≥ 1.5 standard deviations below standardized cognitive testing (e.g., MMSE)
* Diagnosis of MCI
* Clinical Dementia Rating (CDR) ≥ 0.5
* Diagnosis of major depressive disorder
* Beck Anxiety Inventory score ≥ 16
* Other medical or neurological conditions that could explain cognitive decline (e.g., vascular dementia, traumatic brain injury)
* Claustrophobia
* Contraindications of MRI (e.g., non-MRI-compatible cardiac pacemaker or devices implanted within the past three months)

Where it's running

• China Medical University Hospital
  Taichung, Taiwan Recruiting

Study contacts

• Study coordinator: Sheng-Ta Tsai, M.D., Ph.D.
• Email: tshengdar@gmail.com
• Phone: 886-928262460

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.