Condition

Social Isolation clinical trials and research

• 14Clinical trials
• 79NIH research projects
• 7Countries

Newest Social Isolation clinical trials

All recruiting trials (14)

• Social Connection Collective for older adults in subsidized housing

  A resident-led program in subsidized housing in Baltimore will try to build friendships and peer support among residents aged 62 and older to see if it’s feasible and if it reduces loneliness.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07863583

• Three-agent chat app for lonely older adults in Hong Kong

  This trial tests whether a Cantonese-language smartphone chat app with three conversational companions can help reduce loneliness in adults aged 60 and older in Hong Kong, by comparing a version powered by a large language model to a version using pre-written templates.

  Recruiting The University of Hong Kong · Hong Kong, Hong Kong SAR · NCT07822828

• Mindful lifestyle social prescribing for older adults’ mood and connection

  A group program about 8 weeks of mindfulness plus healthy lifestyle activities is tested to see if it helps reduce depressive symptoms and loneliness and improve quality of life in adults aged 55 and over.

  Recruiting Buddhist Tzu Chi General Hospital · Hualien City, Taiwan · NCT07669805

• CAPABLE Care + Connect for older adults experiencing social isolation

  This project will see if combining the CAPABLE home-based support program with Johns Hopkins home-based primary care reduces loneliness and improves daily functioning for older, homebound adults.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07123298

• Sisters of Heart: community health worker support to improve heart health in migrant farmworker women

  This trial tests whether peer support and help accessing community resources from community health workers can reduce stress and improve heart health measures in Spanish- or English-speaking migrant farmworker women aged 18–45.

  Recruiting Emory University · Ellenton, Georgia · NCT07111026

• CONNECT program: group telehealth to reduce loneliness and improve mental health in adults 55+

  This project will test whether the group-based CONNECT telehealth program can reduce loneliness, social isolation, anxiety, and depression in adults 55 and older compared with routine community programming.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07107906

• Qnnections: a 10-week group program to build social connection for LGBTQ+ and other minoritized Veterans

  This project will test whether Qnnections, a 10-week group program, can increase social connection and reduce suicide risk for LGBTQ+ and other minoritized Veterans who have recent suicidal thoughts or behavior.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06803329

• A program to connect people with psoriasis through walking and talking

  This study is trying out a 'Walk and Talk' program for adults with psoriasis to see if it helps them feel more connected and active.

  Recruiting Royal Free Hospital NHS Foundation Trust · London, Greater London · NCT06726213

• Need to Be Needed (N2BN): a program to boost feeling of being needed

  This study will test whether weekly, personalized support to help adults with serious mental illness do acts of kindness and volunteer can reduce loneliness and social isolation.

  Recruiting Temple University · Philadelphia, Pennsylvania · NCT06510439

• Improving social engagement and connectedness among veterans

  This study is testing a new program to help veterans feel less isolated and more connected to others by providing support and resources through telehealth over eight weeks.

  Recruiting VA Office of Research and Development · Indianapolis, Indiana · NCT06467214

• Intervention for opioid use disorder and loneliness

  This study is testing whether different types of therapy can help people with opioid use disorder who feel lonely improve their social connections and overall health.

  Recruiting University of Rochester · Rochester, New York · NCT06458335

• Social Assistance Robot to Help a Child in Prolonged Hospital Isolation

  A social-assistance robot is tested to help children in long hospital isolation and see if it improves the child’s well‑being and family connection.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06405620

• Effects of social isolation and interaction on dementia risk in people with subjective cognitive decline

  This study is trying to see how being socially isolated or interacting with others affects the risk of dementia in people who notice early signs of memory problems.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, China, Jiangsu · NCT06335836

• Using virtual reality to promote physical activity and social connection in adults

  This study is testing whether using virtual reality can help adults aged 45-80 who are not very active to get moving and connect with others while exercising from home.

  Recruiting Wake Forest University · Winston-Salem, North Carolina · NCT04756245

NIH-funded research (newest 40 of 79)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How social isolation affects aging health in schizophrenia

  This project explores how being socially isolated may speed up health problems as people with schizophrenia age.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11551517

• How Social Isolation Impacts Aging in People with Schizophrenia

  This study looks at how social isolation affects aging and health in people with schizophrenia to see if loneliness and lack of social contact worsen medical problems as they grow older.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11551516

• How social isolation affects aging health in schizophrenia

  A patient-friendly look at how being socially isolated might influence aging and health in people with schizophrenia.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11551515

• The effect of social isolation on aging health in people with schizophrenia

  This study explores how being socially isolated may speed up aging-related health problems in people with schizophrenia.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11551514

• UCSF Prevention Center to Reduce Loneliness in older LGBTQ+ adults

  A center at UCSF will partner with communities to reduce loneliness and social isolation among LGBTQ+ adults ages 60 and up.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11500983

• Genetic and brain factors behind how people respond to social isolation

  A study to understand why some individuals respond differently to social isolation by looking at genes and brain circuits.

  NIH research Duke University · Durham, United States · NIH-11428380

• Strengthening Bonds: A telephone reminiscence program to reduce loneliness in rural older adults

  A phone-based program helps rural adults 21+ stay socially connected and improve mental health with guided conversations about their life memories.

  NIH research Storii, INC. · San Mateo, United States · NIH-11419818

• A practical, online program to reduce loneliness and improve mental health for older adults living with HIV

  A small, online program helps older adults with HIV stay connected and healthier by combining social activities with a simple mental-health support approach.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11407223

• How isolation and COVID-19 affected suicide risk in youth

  This project looks at how social isolation during the COVID-19 era may influence suicide risk among people aged 21 and younger.

  NIH research Appalachian State University · Boone, United States · NIH-11406129

• Social isolation and its impact on Alzheimer’s and related dementias

  This grant explores how feeling socially isolated may influence the risk of developing Alzheimer's disease and related dementias and how interventions could help reduce disparities.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11399299

• How social connections and loneliness affect thinking in older adults

  A study of how feeling lonely and actually having few social contacts influence thinking skills and risk of dementia in older adults.

  NIH research Northwestern University · Chicago, United States · NIH-11393680

• Disclosing Recovery: A Tool to Reduce Social Isolation for People Receiving Opioid Use Disorder Treatment

  A guided, one-hour intervention helps people in treatment for opioid use disorder decide how and when to talk about their OUD history to reduce loneliness and support recovery.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11390951

• How social isolation affects aging health in schizophrenia

  This research looks at how being isolated socially might influence health and aging in people with schizophrenia.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11383120

• Trajectories of loneliness and social isolation in older adults with HIV who use methamphetamine

  This study follows older adults living with HIV who use methamphetamine to understand how loneliness and isolation change over time and relate to health care use and wellbeing.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11382958

• Understanding how social isolation and loneliness affect brain health in Alzheimer’s risk

  This research looks at how feeling isolated or lonely and the social environment might influence brain changes related to Alzheimer’s disease in adults.

  NIH research New York University School of Medicine · New York, United States · NIH-11381583

• Understanding how social isolation changes health through fruit-fly models

  A study using fruit flies to uncover the brain and biology behind how long social isolation affects sleep and eating, with potential relevance to human health.

  NIH research Texas A&m University · College Station, United States · NIH-11380811

• Aging, Homelessness, and Trust in Care

  This project follows older adults who are experiencing homelessness to understand how trust in healthcare affects their health and access to care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11375030

• How social isolation affects aging and health in people with schizophrenia

  This project is tracking whether loneliness and lack of social contact are linked to earlier health problems in older adults living with schizophrenia.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11371749

• Social connections and health in older adults with schizophrenia

  This project will look at whether being socially isolated speeds up health problems as people with schizophrenia get older.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11371739

• How loneliness affects aging and health in people with schizophrenia

  Researchers are seeing if lack of social contact speeds up physical health problems in older adults with schizophrenia.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11371731

• Social isolation and aging in people with schizophrenia

  Looking at whether being socially isolated speeds up health problems as people with schizophrenia get older.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11371709

• Social factors and brain health: how loneliness and social support affect stroke risk and recovery

  Researchers will study how social isolation and lack of support influence brain injury, stroke risk, and recovery in people over 21, using long-term data from large population studies.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11347561

• Short telehealth CBT to reduce loneliness for people with opioid use disorder

  It sees if a brief, telehealth cognitive-behavioral program can reduce loneliness for people with opioid use disorder.

  NIH research University of Rochester · Rochester, United States · NIH-11320769

• Dyadic approach to reduce stress and loneliness in breast cancer survivors and families

  A family-focused program helps breast cancer survivors and their caregivers cope with stress and isolation using a web-based, collaborative approach.

  NIH research Stanford University · Stanford, United States · NIH-11314527

• Using smartphones to spot isolation and loneliness linked to Alzheimer’s risk

  This project uses brief smartphone surveys and passive phone sensors to find patterns of loneliness and social isolation that may signal higher Alzheimer's risk in older adults with normal thinking.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11297690

• How early social isolation changes brain wiring in the front part of the brain

  Researchers are learning how childhood social isolation can change the brain's insulation and circuits and lead to lasting social and thinking problems.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11266175

• Understanding loneliness and social isolation in people with dementia

  This project looks at how feeling lonely and having fewer social contacts affects people living with Alzheimer's disease and related dementias and their caregivers.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11265779

• Reducing social isolation in young adults facing health disparities

  This project tries to use short health messages to encourage young adults from underserved groups to meet in person and feel less lonely.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11238486

• Using AI on health record notes to find loneliness and suicide risk in older adults

  This project uses artificial intelligence to read doctors' notes and medical records to spot loneliness and help reduce suicide risk for older adults.

  NIH research Emory University · Atlanta, United States · NIH-11231275

• How social isolation and discrimination affect obesity through the brain-gut microbiome in Filipino and Mexican American women

  This study is looking at how feeling lonely and facing discrimination affects eating habits and health, especially for Mexican and Filipina women who may be more likely to struggle with obesity, and it involves surveys, food diaries, and some health tests to better understand these connections.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11202830

• How social isolation and loneliness affect Alzheimer's risk and health disparities

  This project looks at whether being socially isolated or lonely raises the chance of developing Alzheimer's disease and related dementias in older adults and whether it helps explain differences across groups.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11189747

• Helping people in opioid treatment safely share their recovery and rebuild connections

  A one-hour program to help people in opioid treatment decide when and how to tell others about their recovery to reduce isolation and support getting better.

  NIH research University of Delaware · Newark, UNITED STATES · NIH-11170550

• Early social isolation and brain changes tied to later addiction risk

  This project looks at how being socially isolated early in life can change brain wiring in ways that may raise the chance of substance use problems later on.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11169979

• How social isolation affects aging and health in people with schizophrenia

  This project looks at whether being socially isolated makes people with schizophrenia develop age-related health problems earlier.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11161436

• How social isolation affects the brain's response to touch

  This study looks at how being socially isolated might change the way our brains respond to touch, especially for those who feel more sensitive to it, and it aims to understand the brain's inner workings behind this experience.

  NIH research Salk Institute for Biological Studies · La Jolla, UNITED STATES · NIH-11146325

• Understanding social isolation and cognition in adolescents with Tourette syndrome

  This study looks at how feeling alone affects teenagers with Tourette syndrome and how well they understand social situations, hoping to find ways to help them connect better with others.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11137898

• Building social connections for older LGBTQ+ adults

  UCSF will bring proven peer-support and community programs to help older LGBTQ+ adults feel less lonely and more connected.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11136807

• Pandemic isolation and memory in older Veterans with and without Alzheimer's

  This project looks at how COVID-19 social isolation affected thinking and memory in older Veterans with and without Alzheimer's disease.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11132620

• How social isolation affects brain development and behavior in children

  This study is looking at how being socially isolated as a child affects brain development, especially in areas that help with memory and social skills, and it's for anyone interested in understanding how loneliness might impact mental health over time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11127680

• Using telehealth to reduce loneliness in people with opioid use disorders

  This study is looking at how feeling lonely affects people with opioid use disorders and is testing a new online therapy to help them feel more connected and improve their recovery.

  NIH research University of Rochester · Rochester, United States · NIH-11117106

Related topics

Quick answers

How many Social Isolation clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (8 trials), Taiwan (1 trial), Canada (1 trial), China (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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