Identifying early signs of Alzheimer's disease using advanced imaging and biomarker analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop diagnostic and prognostic models for identifying individuals at high risk of progressing from preclinical stages of Alzheimer's disease to mild cognitive impairment and dementia. By utilizing a combination of demographic, cognitive, behavioral, multimodal MRI, genetic, and plasma biomarker data, the research seeks to uncover the neural mechanisms and biological pathways involved in Alzheimer's progression. Advanced analytical methods will be employed to analyze MRI data and explore the interaction effects of genetic risk factors. The ultimate goal is to enhance early diagnosis and intervention strategies for Alzheimer's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The inclusion criteria were 50-79 years old and having 8 or more years of education.

Exclusion Criteria:

* Participants with a history of stroke, other neurological disorders that could lead to cognitive impairment (Parkinson's disease, encephalitis, epilepsy, brain tumors, etc.), severe anxiety or depression, and contraindications for magnetic resonance imaging (MRI) were not enrolled.

Where it's running

• Nanjing Drum Tower Hospital
  Nanjing, Jiangsu, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.