Effects of social isolation and interaction on dementia risk in people with subjective cognitive decline

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how social isolation and social interaction influence the risk of dementia progression and brain function in individuals experiencing subjective cognitive decline (SCD). It will utilize a cohort study design to assess the degree of social isolation among SCD patients and analyze its impact on the progression to mild cognitive impairment (MCI) or Alzheimer's disease (AD) over a follow-up period of 3-5 years. The study will also explore the relationship between brain connectivity characteristics and the APOEε4 genotype in relation to cognitive decline. Additionally, a predictive model will be developed to identify risk factors for progression from SCD to MCI and AD, allowing for individualized interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* SCD

  1. Self-perceived continuous cognitive decline compared with the previous normal state, and is not related to acute events;
  2. After adjustment for age, gender, and years of education, the standard cognitive test is normal, or the diagnostic criteria for MCI are not met;
  3. Selected candidates can sign the informed consent form themselves.

Exclusion Criteria:

* (a) Aged under 45 years or older than 85 years; (b) Vascular dementia or other central nervous system diseases; (c) Hachinski Ischemic Scale score \> 4 points; (d); Unable to complete neuropsychological tests (e.g., blindness, deafness, severe language impairment); (e) Drug abuse or alcohol dependency within the last 6 months; (f) Current participation in other cognition studies; (g) Severe diabetes mellitus, or severe cardiovascular disease, cerebrovascular disease, liver diseases, kidney diseases, psychiatric disorders; (h) Contraindications to imaging techniques: claustrophobia, metallic implants (e.g., intracranial metal clips), electronic devices (e.g., cardiac pacemakers)

Where it's running

• The First Affiliated Hospital of Nanjing Medical University
  Nanjing, China, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Zhu Yi
• Email: ZhuYi1981@njmu.edu.cn
• Phone: +86 137 0516 4030

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.