Understanding cognitive decline and mild cognitive impairment in Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the phases of subjective perception of cognitive decline and mild cognitive impairment associated with Alzheimer's disease. It involves assessing cognitively healthy individuals, those with subjective cognitive decline, mild cognitive impairment, and mild dementia. Participants will be evaluated through subjective memory complaints and clinical interviews, with the involvement of a relative to provide additional insights. The study seeks to enhance understanding of the progression of cognitive decline in Alzheimer's disease without any direct interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Men and women between 45 and 74 years at the time of inclusion in the 45-65/FPM2012 study or older than 45 for persons who have not previously participated in 45-65/FPM2012.
2. Cognitively healthy persons with SCD, as well as people with MCI and mild dementia.
3. Participation of a relative to perform the subjective memory complaint and clinical interview.

Exclusion criteria:

1. Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol.
2. Any significant disorder that could course with cognitive impairment that is not related to AD.
3. Family history of monogenic AD.

Where it's running

• Barcelonabeta Brain Research Center
  Barcelona, Catalonia, Spain Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.