NIH-funded research R01 grant

Understanding cognitive decline in older Hispanics/Latinos

Official title: Subjective Cognitive Decline and Objective Cognitive Trajectories in Older Hispanics/Latinos

Funded at University of California, San Diego · NIH-11012375 · Data updated 2026-11-12

This study is looking at how older Hispanic and Latino individuals feel about their thinking skills and how those feelings connect to actual changes in their memory and thinking, with the goal of spotting early signs of Alzheimer's disease to help with better diagnosis and care.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego
NIH-funded
Lab location1 site (La Jolla, United States)
Project startFebruary 1, 2021
Project endJanuary 31, 2026
Funding year2025
Award (this year)$663,961
NIH project number5R01AG066657-05
Project IDNIH-11012375 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are older Hispanics/Latinos who may be experiencing changes in their cognitive function.

Less likely to help

Patients who are not of Hispanic/Latino descent or who do not have concerns about cognitive decline may not benefit from this research.

What this research studies

This research investigates how older Hispanics/Latinos perceive changes in their cognitive abilities and how these perceptions relate to actual cognitive decline. The study aims to identify early risk markers for Alzheimer's disease by focusing on subjective cognitive decline (SCD) and its variations across different cultural backgrounds. By gathering data from this underserved population, the research seeks to improve early detection and diagnosis of cognitive impairments, ultimately contributing to better health outcomes. Participants will be asked about their cognitive experiences and undergo assessments to track their cognitive health over time.

Why it matters

Potential benefit: If successful, this research could lead to better early detection methods for Alzheimer's disease in older Hispanics/Latinos, allowing for timely interventions.

How similar studies have gone: While there has been some research on cognitive decline in other populations, this study focuses specifically on Hispanics/Latinos, making it a novel approach in this context.

Where this research is happening

  • University of California, San Diego
    La Jolla, United States
    Active

Researchers

  • Principal investigator: Zlatar, Zvinka Zoe — University of California, San Diego
  • Study coordinator: Zlatar, Zvinka Zoe

Related research

Other NIH-funded projects on the same topics.

  • Predicting Early Dementia Risk from Health Records Using AI

    A plan to use big health records and smart computer methods to spot people who may be in the early stages of memory decline before dementia

    NIH research Brigham and Women's Hospital · Boston, United States · NIH-11399877

  • Tracing early memory concerns and outcomes using health records and AI

    Researchers are using electronic health records and artificial intelligence to find adults with early memory worries and identify who may later develop dementia.

    NIH research Brigham and Women's Hospital · Boston, United States · NIH-11176369

  • Understanding early signs of cognitive decline using health records and AI

    This study is looking at how electronic health records can help spot early signs of memory problems that might lead to Alzheimer's and similar conditions, so we can find people who need support before they get a formal diagnosis.

    NIH research Brigham and Women's Hospital · Boston, United States · NIH-11121163

  • Creating an online mindfulness program for adults experiencing cognitive decline

    This study is testing an online mindfulness program to help adults who feel their thinking skills are slipping, with the hope that it can improve their focus and possibly benefit their brain health, while also comparing it to a group learning about healthy lifestyles.

    NIH research Ohio State University · Columbus, UNITED STATES · NIH-11063290

  • Investigating how sleep and physical frailty affect cognitive decline in older adults

    This study is looking at how sleep problems and physical weakness in older adults with early signs of memory issues might affect their thinking skills and risk of developing dementia, with the goal of finding ways to help them stay mentally sharp longer.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-10973042

  • Understanding early cognitive changes in Alzheimer's disease

    This study is looking at how people notice changes in their thinking skills, especially in the early stages of Alzheimer's, and it’s for anyone who has concerns about their memory; you'll share your thoughts on your cognitive abilities every few months using a device, and the researchers will compare what you say with

    NIH research Brigham and Women's Hospital · Boston, United States · NIH-10762473

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.